MAGNOLIA FLOWER

Allergic reactions to magnolia flower bud have been reported (Bensky et al. 2004). 

Magnolia flower bud should be used with caution in pregnancy (Bensky et al. 2004). Uterine stimulant activity of magnolia flower bud has been observed in an animal study (Chen and Chen 2004). Use during pregnancy is therefore not recommended except under the supervision of a qualified healthcare practitioner. 

No information on the safety of magnolia flower bud during lactation was identified. While this review did not identify any concerns for use while nursing, safety has not been conclusively established. 

Inhibition of the drug-metabolizing isoenzyme CYP2D6 was observed in rat liver microsomes treated with an extract of magnolia flower (Yu et al. 2007). 

No information on the safety of magnolia flower bud during lactation was identified. 

The LD50 of intravenously administered magnolia flower bud could not be determined at doses up to 1 g/kg in dogs and 4.75 g/kg in rabbits (Chen and Chen 2004). 

No adverse effects were observed in rats orally administered 18 g/kg of an alcohol extract or 30 g/kg of a water extract of magnolia flower bud daily for 30 days (Chen and Chen 2004). 

Common/vernacular names Magnolia flower bud, xinyi, xinyihua, shin-i, and flos magno-liae. 

Small to large trees, mostly deciduous, widely distributed in China some extensively cultivated. At least 10 species of Magnolia serve as source of magnolia flower. However, M. biondii, M. denudata, and M. sprengeri are currently the major sources andM. liliflora Desr., although still listed in many major works as the major source, is not a current source. Produced mainly in eastern and southern provinces in China. 

Magnolia salicifolia is source of Japanese magnolia flower. ... 

Magnolia flower in various forms (decoction, alcoholic extract, volatile oil, etc.) and in combination with other herbal drugs has been reported highly effective both locally and internally in treating allergic rhinitis (e.g., hay fever), chronic rhinitis, and paranasal sinusitis (WANG). °... 

Magnolia flower has very low toxicity i.v. injection of decoction in dogs (l.Og/kg) and rabbits (4.75 g/kg) produced no fatalities. The LD50 (i.p.) of its tincture (after alcohol removal) in rats and mice were 22.5 0.96 and 19.9 0.25 g/kg, respectively, based on the crude drug (wang). 

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