Magnetic resonance imaging observational studies

A functional magnetic resonance imaging (fMRI) study of the brain can actually determine between the regular and the occasional coffee drinker. Caffeine consistently slows blood flow by 25% to the gray matter of the brain, which contains the cells, and by 20% to the white matter, which contains the connecting nerve fibers. Heavy users of caffeine show more blood flow in the gray matter in the front of the brain when they had abstained for 30 hours, compared to those who infrequently ingest caffeine. With fMRI, the doctor can look inside the brain and observe the phenomenon of caffeine withdrawal in action. 

Table 4 lists the changes in brain magnetic resonance imaging (MRI) studies that have been observed during DHA therapy. Four of the patients whose ages ranged from... 

A variety of neuroanatomic differences have been observed in samples of autistic patients in comparison with controls. This topic has been reviewed in recent publications [43-45]. Magnetic resonance imaging (MRI) studies show that by 2-4 years of age, 90% of autistic children have an abnormal early brain overgrowth followed by abnormally slowed growth [45, 46]. The most common finding has been hyperplasia of cerebral gray matter and cerebral and cerebellar white matter in the early life of autistic patients [46]. 

Boesch SM, Plorer AL, Auer AJ et al. (2003). The natural course of Sneddon syndrome clinical and magnetic resonance imaging findings in a prospective six year observation study. Journal of Neurology, Neurosurgery and Psychiatry 74 542-544... 

In the rabbit brain safety study using P(CPP-SA) 50 50 copolymer, even less of an inflammatory reaction was observed, and the polymer was essentially equivalent to Gelfoam [94]. In a similar brain biocompatibility study conducted in monkeys, no abnormalities were noted in the computer tomography scans and magnetic resonance images, nor in the blood chemistry or hematology evaluations [95]. No systemic effects of the implants were observed on histological examinations of any of the tissues tested [96]. No unexpected or untoward reactions to the treatments were observed. 

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