Hematology, evaluation

No abnormalities were noted in any of the computer-assisted tomography scans or magnetic resonance images, nor in the blood chemistry or hematology evaluations. No systemic effects of the implants were noted on histological examination of any of the tissues exaoiined. No unexpected or untoward reactions to the treatments were observed. 

Hematologic evaluation was performed on Sprague-Dawley rats that received 20 ppm... 

Hematology Evaluate baseline and periodic blood studies approximately every 2 days during therapy. Discontinue the drug upon appearance of reticulocytopenia, leukopenia, thrombocytopenia, anemia, or any other findings attributable to... 

Hematologic evaluation of swine treated with an unspecified PBB mixture for 16 w eeks showed significantly decreased hemoglobin and hematocrit values in two of four animals exposed to 8 mg/kg/day at week 6, after which values returned to normal or near-normal within 2 weeks (Ku et al. 1978). 

Hematological Effects. Hematological evaluations of workers occupationally exposed to chromium compounds have yielded equivocal results. Ninety-seven workers from a chromate plant were exposed to a mixture of insoluble chromite ore containing chromium(III) and soluble sodium chromate and dichromate. Hematological evaluations revealed leukocytosis in 14.4% or leukopenia in 19.6% of the workers. The leukocytosis appeared to be related primarily to monocytosis and eosinophilia, but controls had slight increases in monocytes and occasional increases in eosinophils without leukocytosis. 

Results from hematological evaluations in rats were also equivocal. Hematological evaluations of rats exposed to sodium dichromate at 0.025-0.2 mg chromium(VI)/m3 for 28 or 90 days or 0.1 mg chromium(VI)/m3 for 18 months were unremarkable (Glaser et al. 1985,1986, 1988). However, increased white blood cell counts were found in rats exposed to 0.1 mg chromium(VI)/m3 as sodium dichromate for 30 days and at 0.05 mg chromium(VI)/m3 for 90 days. The white blood cell counts were not increased 30 days postexposure (Glaser et al. 1990). Rats exposed to 0.1 mg chromium/m3 as a 3 2 mixture of chromium(VI) trioxide and chromium(III) oxide for 18 months had increased red and white blood cell counts, hemoglobin content, and hematocrit (Glaser et al. 1986,1988). 

Brookoff D. Hematologic evaluation. In Flomenbaum N, Goldfrank L, Jacobson S, eds. Emergency Diagnostic Testing. 2nd Ed. St. Louis, MO Mosby, 1995. 

Clinical observations Clinical pathology Hematology Serum chemistry Urine chemistry Weights for seven major organs Microscopic evaluation of 17 tissues from major organ systems Twelve hematology evaluations Seventeen blood chemistry analyses Eleven urine chemistry analyses... 

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