Cerebellar white matter

The areas of the brain that retained the greatest concentrations of the label after intravenous Injection of [ H]BZ Into cats (16) were motor cortex, sensory cortex, caudate nucleus, lateral geniculate, and medial geniculate Smaller concentrations were retained In thalamus, hippocampus, hypothalamus, medulla oblongata, colliculi, cerebellar cortex, the pyramids of the medulla, cerebral white matter, and cerebellar white matter ... 

Reports of necrotizing leukoencephalopathy in association with methotrexate have been verified by biopsy or autopsy (25,26). Serial electroencephalography can predict this, since slow-wave activity develops during the administration of high-dose methotrexate. Autopsy has shown widespread necrosis and spongiosis in the cerebral and cerebellar white matter in such cases (25). 

Noebels Was there an effect of plaques in the cerebellar white matter Why would they turn on a new channel ... 

NA. A heavy plexiform innervation of the granular layer by thin varicose axons and parallel fiber-like fluorescence in the molecular layer was also found in chicken cerebellum. The parent fibers in the cerebellar white matter were concentrated in two parasagittal bundles (Mugnaini and Dahl, 1975). 

Fig. 126. Zones and compartments in the paraflocculus of the ferret. Cj, D, and Dj zones indicated on surface of caudal (A) and rostral (C) aspect of the paraflocculus with different shadings. B and D. Reconstructions of the compartmental borders in the cerebellar white matter. ANS = ansiform lobule FLO = flocculus PFLD = dorsal paraflocculus PFLV = ventral paraflocculus PMD = paramedian lobule. Voogd (1969). Drawings by J. Tinkelenberg.

Feirabend HK, Voogd J (1986) Myeloarchitccture of the cerebellum of the chicken (Gallus domesticus) an atlas of the compartmental subdivision of the cerebellar white matter. J. Comp. Neurol, 251, 44-66. 

A variety of neuroanatomic differences have been observed in samples of autistic patients in comparison with controls. This topic has been reviewed in recent publications [43-45]. Magnetic resonance imaging (MRI) studies show that by 2-4 years of age, 90% of autistic children have an abnormal early brain overgrowth followed by abnormally slowed growth [45, 46]. The most common finding has been hyperplasia of cerebral gray matter and cerebral and cerebellar white matter in the early life of autistic patients [46]. 

High levels of lead exposure can cause overt clinical encephalopathy in both children and adults. The effects include brain edema and demyelination of the cerebral and cerebellar white matter, which are thought to be secondary to vascular injury (Reyes et al., 1986). 

Borner, K., Nygren, H., Hagenhoff, B., Malmberg, P, Tallarek, E., Mansson, J.-E. (2006) Distribution of cholesterol and galactosylceramide in rat cerebellar white matter. Biochim. Biophys. Acta, 1761,335-344. 

Cytosolic Liver kidney (cortical proximal tubule) intestine myenteric neu-ronsi ileal and colonic muscles CNS not in astrocytes (selective neurons in neocortex, and midbrain), brainstem, diencephalon, cerebellar molecular and granular layer eye Fibroblasts Cytosolic Liver kidney (cortical proximal tubule) intestine, myenteric neurons, ileal and colonic muscles CNS cerebrum ubiquitous, cerebellum (not in cerebellar white matter) eye Red cells, fibroblasts Arginase 1 cytosol (liver)... 

CYP2C9 polymorphisms have also been associated with a significant reduction in cerebellar white matter volume, but not in total cerebellar volume, in patients taking phenytoin... 

Histopathology. Microscopic alterations in the two brains were remarkably similar except for minor differences in the severity of involvement. The principal findings consisted of the presence of large numbers of heterotopic neurons in cerebral and cerebellar white matter and disturbances of cerebral and cerebellar cortical neuronal dignment and organization. 

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