Magnesium tablets, compound

The sodium salt of valproate is marketed in Europe as a tablet and is quite hygroscopic. In Central and South America, the magnesium salt is available, which is considerably less hygroscopic. The free acid of valproate was first marketed in the USA in a capsule containing corn oil the sodium salt is also available in syrup, primarily for pediatric use. An enteric-coated tablet of divalproex sodium is also marketed in the USA. This improved product, a 1 1 coordination compound of valproic acid and sodium valproate, is as bioavailable as the capsule but is absorbed much more slowly and is preferred by many patients. Peak concentrations following administration of the enteric-coated tablets are seen in 3-4 hours. Various extended-release preparations are available not all are bioequivalent and may require dosage adjustment. 

Ascorbic acid samples as well as binary mixtures of ascorbic acid and the considered excipients were investigated. The binary mixtures were prepared taking into account the shoichiometry generally used for the preparation of ascorbic acid tablets ascorbic acid (500 mg, of a 100 mesh sample), magnesium stearate (6.7 mg), magnesium trisilicate (13.3 mg), and Si02 (1.0mg). The compounds were mixed in a mortar. 

Based on the TG and DSC experimental results it can be concluded that the excipients, that is, magnesium stearate, magnesium trisilicate, and Si02, have no substantial influences on the thermal stabihty of ascorbic acid. This result shows that the three compounds can be used (at least from a thermal point of view) as excipients, with no restrictions, for ascorbic acid tablet formulations, since they will not provoke or accelerate the thermal degradation of ascorbic acid. However, by comparison of Tables 3.5 and 3.7, it is evident that the temperature of the... 

Compound Tablets of Magnesium Carbonate, B.P.C. Each tablet contains 3 grains each of heavy magnesium carbonate and calcium carbonate, 2 grains of sodium bicarbonate and 1 grain each of light kaolin and ginger. 

For sodium bicarbonate To 1 g of powdered tablets, add 100 ml of water and heat at 50° for five minutes. Filter, transfer the residue to a beaker, add 100 ml of water and again heat at 50° for five minutes. Filter, cool and complete as for Compound Powder of Magnesium Carbonate above, beginning with the words titrate the combined filtrates. . ... 

---