Magainins applications

From the data presented in Figure 3, it is likely that heat-stable LAB bacteriocins (other than nisin) may find suitable application as biologically-produced antimicrobials ("biopreservatives") in thermally-processed foods. Future studies directed towards the examination of a variety of novel bacteriocins in thermal processing applications may identify new LAB bacteriocin(s) which have comparable, or perhaps superior, properties as nisin. Further research is needed to determine the presence of bacteriocins in retail foods which may help to reduce the regulatory hesitancy towards their practical application as safe food ingredients. Data provided by research with the magainins and... 

Also, Eli Lilly Co. (Indianapolis, IN) now has a small-molecule agent for the central nervous system in human Phase II/III trials, which took less than two years to identify and enter into the trials. In addition, Magainin Pharmaceuticals (Exton, PA) has developed a novel antibacterial drug lead through the application of combinatorial chemistry that is in Phase I/Il trials. 

Antibiotic-resistant bacteria cause life-threatening infections in hospitals and society in general. There is a vital requirement to develop new antimicrobial agents, but this task involves extensive scientific trials. This chapter reviewed broad-spectrum polymeric antimicrobials, which are not susceptible to current resistance, and mechanisms of bacteria to mimic the antimicrobial action of natural HDP, which exert their effect by permeabilising the bacterial cytoplasmic membrane. Most cationic antimicrobial polymers appear to work in a manner similar to membrane-active AMP, such as magainin. The design and synthesis of different polymers, such as methacrylate-based copolymers, PPE, polynorbornene by-products, amphiphilc arylamide polymers and large polymers, have been studied as biomimetic polymers in different applications. 

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