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M-AMSA

The major class of topoisomerase I inhibitors comprise of the camptothecins, while topoisomerase II inhibitors fall into several classes - anthracyclines (e.g. doxorubicin), anthracenediones (mitoxantrone), anthrapyrazoles (bianthrazole), actinomycins (actinomycin D), acridines (m-AMSA), ellipticines (9-hydroxy-ellipticine) and epidophyllotoxins (Etoposide (VP-16) and VM-26). The chemical... [Pg.174]

Amsacrine (m-AMSA) is a synthetic aminoacri-dine which intercalates into DNA and inhibits DNA topoisomerase II. m-AMSA is not cross-resistant to anthracyclines and has been particularly active in acute non-lymphocytic leukemia. Amsacrine is administred by intravenous infusion. It is metabolized in the liver and eliminated in the bile with an elimination half-life of 6-9 hours. Its major toxicity is bone marrow depression. Gastrointestinal disturbances are frequent. Neurotoxicity and cardiotoxic-ity may occur. [Pg.457]

Amsacrine (= 4 -(9-Acridinylamino)methan-sulfon-m-anisidine m-AMSA)... [Pg.362]

Amsacrine (= m-AMSA 4 - Synthetic TOPII (formation of cleavable... [Pg.376]

Among the newer untineoplustic drugs. 4-l(9-acridinyl)-amino mcthancsulfon- i-anisididc (m-AMSA) showed a wide spectrum of activity in early clinical trial.s. It afforded. some remissions in refractory cases of breast cancer, malignant melanoma, and acute myelocytic leukemia. Leukopenia is the limiting toxicity. ... [Pg.429]

In the presence of several drugs known for their antitumor activities, calf thymus topoisomerase II has been shown to cleave DNA more efficiently (Nelson et al., 1984 Chen et al., 1984). These drugs include both DNA intercalaters like ellipticine and 4 -(9-acridinylamino)methane-sulfon-wi-aniside (m-AMSA), and nonintercalative compounds such as the epipodophyllotoxins VP-16 and VM-26. The drug m-AMSA had... [Pg.85]

Poot, M., Epe, B., and Hoehn, H., Cell cycle effects ofthe DNA topoisomerase inhibitors camptothecin and m-AMSA in lymphoblastoid cell lines from patients with Fanconi anemia, Mutat. Res., 270, 185, 1992. [Pg.239]

Table 1). However, m-AMSA a potent antitumour agent, chloroquine, and ethidium bromide have essentially no effect on the enzyme activity. [Pg.156]

I. Chourpa, H. Moijani, J.F. Riou, M. Manfait, Intracellular molecular interactions of antitumor drug amsacrine (m-AMSA) as revealed by surface-enhanced Raman spectroscopy. FEES Lett. 397, 61 (1996)... [Pg.146]

See other pages where M-AMSA is mentioned: [Pg.116]    [Pg.32]    [Pg.116]    [Pg.429]    [Pg.429]    [Pg.977]    [Pg.95]    [Pg.99]    [Pg.99]    [Pg.108]    [Pg.86]    [Pg.86]    [Pg.91]    [Pg.85]    [Pg.154]    [Pg.155]    [Pg.89]    [Pg.220]    [Pg.295]   
See also in sourсe #XX -- [ Pg.447 ]

See also in sourсe #XX -- [ Pg.116 ]



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