Lysophosphatidic receptor

Hama, K., Aoki, J., Bandoh, K., Inoue, A., Endo, T., Amano, T., Suzuki, H., Arai, H. Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus. Life Sci 79 (2006) 1736-1740. 

Moughal, NA, Waters, C, Sambi, B, Pyne, S and Pyne, NJ (2004) Nerve growth factor signalling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems Nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells. Cellular Signalling, 16, 127-136. 

Edg receptors are a group of recently discovered G-protein coupled receptors, which mediate the action of lysophospholipids (sphingosine-1 -phosphate, lysophosphatidic acid). Tachykinins and their Receptors... 

Parrill AL, Sardar VM, Yuan H (2004) Sphingosine 1-phosphate and lysophosphatidic acid receptors agonist and antagonist binding and progress toward development of receptor-specific ligands. Semin Cell Dev Biol 15 467-476... 

Most GPCRs interact with and activate more than one G-protein subfamily, e.g., with Gs plus Gq/n (histamine H2, parathyroid hormone and calcitonin recqrtors), Gs plus G (luteinising hormone receptor, 32-adrenoceptor) or Gq/11 plus G12/13 (thromboxane A2, angiotensin ATb endothelin ETA receptors). Some receptors show even broader G-protein coupling, e.g., to Gi, Gq/n plus Gi n ( protease-activated receptors, lysophosphatidate and sphingosine-1-phosphate receptors) or even to all four G-protein subfamilies (thyrotropin receptor). This multiple coupling results in multiple signaling via different pathways and in a concerted reaction of the cell to the stimulus. 

Hecht, J. H., Weiner,J. A., Post, S.R. and Chun. /Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. /. Cell Biol. 135 1071-1083,1996. 

Guo, Z., Liliom, K., Fischer, D. J. etal. Molecular cloning of a high-affinity receptor for the growth factor-like mediator lysophosphatidic acid from Xenopus oocytes. Proc. Natl Acad. Sci. U.S.A. 93 14367-14372,1996. 

An, S., Dickens, M. A., Bleu, T., Hallmark, O. G. and Goetzl, E. J. Molecular cloning of the human EDG2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun. 231 619-622, 1997. 

Cunnick, J.M., Dorsey, J.F., Standley, T., Turkson, J., Kraker, A.J., Fry, D.W., Jove, R., and Wu, J., 1998, Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway, J. Biol. Chem. 273 14468-14475. 

An, S., Goetzl, E.J. and Lee, H., 1998, Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. 

Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. /. Biol. Chem. 279, 28831-28834. 

Yamada, T., Ohoka, Y., Kogo, M., and Inagaki, S. (2005). Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)./ Biol. Chem. 280,19358-19363. 

Diagrammatic representation of actions of VEGF and receptors. Abbreviations HIF-1, hypoxia-inducible factor LPA, lysophosphatidic acid ox-LDL, oxidized low-density PAl, plasminogen activation inhibitor PIGF, placental growth factor VEGF, vascular endothelial growth factor. 

Nakane, S., Oka, S., Arai, S., Waku, K., Ishima, Y., Tokumura, A., and Sugiura, T. (2002). 2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid Occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain. Arch. Biochem. Biophys. 402, 51-58. 

Noguchi, K., S. Ishii, andT. Shimizu. 2003. Identification of P2Y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278, 25600-25606. 

A.Gohla, R Harhammer, and G. Schultz. The G-protein G13 but not G12 mediates signalling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J Biol Chem, 273,4653,1998. 

Yokoyama K, Baker DL, Virag T, Liliom K, Bytm HS, Tigyi G, Bittman R. Stereochemical properties of lysophosphatidic acid receptor activation and metabolism. Biochim. Biophys. Acta, 2002 1582 295-308. 

Lee CW, Rivera R, Gardell S, Dubin AE, Chun J. GPR92 as a new G12/13.- and Gq.-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J. Biol. Chem. 2006 281 23589-23597. 

Hanahan D. A Guide to Phospholipid Chemistry. Academic Press, 1998. Eukushima, N, Ishii, I, Contos, JJ, Weiner, JA, Chun, J. Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 2001 41 507-34. Moolenaar, WH, van Meeteren, LA, Giepmans, BN. The ins and outs of lysophosphatidic acid signaling. Bioessays. 2004 26 870-81. 

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