Lymphocytes passive transfer

It now appears certain that destruction of malaria parasites in vivo depends in part, if not wholly, upon the presence of humoral antibodies, and this must explain the success achieved with the passive transfer experiments. The exact role of the T and B lymphocytes in immunity in malaria infection in man still needs clarification. In rats the ability to resist P. berghei infection seems to be thymus dependent, and higher parasitemias were encountered in the thymectomized rats, which also developed severe anemia (B6). 

Tanaka K, Tanaka M, Igarashi S, Onodera O, Miyatake T, Tsuji S. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 2. Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice. Clin Neurol Neurosurg 1995 97(1) 101-105. 

In a subject with rhinitis, conjunctivitis and asthma due to phthalic anhydride and giving immediate skin and bronchial reactions to appropriate solutions, Maccia et al. (1976) have obtained a positive RAST for specific IgE antibodies to a conjugate of phthalic anhydride and bovine serum albumin. Passive transfer of skin test sensitivity to phthalic anhydride has been reported (Kern 1939), and lymphocyte transformation has also been reported (Gervais et al. 1972). 

Cellular passive transfer gives more positive results when the number of injected lymphocytes is great (Skog, 1955). It is successful even if the lymphocytes have been lysed by sonic vibration (Jeter, Tremaine and Seebohm, 1954). 

Meneghini, C. L., and G. Cozza The passive transfer of the allergic contact-type sensitivity, with particular regard to the passive transfer by means of human lymphocytes. Read at Vlth international Congress of Allergology Stockholm, sept. 5—9, 1965. 

In a more far-reaching area, a number of case reports suggest that transfer of allergen-specific IgE-mediated hypersensitivities can take place by bone marrow transplantation (110-113). More recently, the transfer of allergen-specific donor lymphocytes was believed to be the most likely mechanism for the transfer of allergy to peanuts to a patient receiving a combined transplantation of liver and kidney. Passive transfer of IgE was regarded to be unlikely however, donor-bound IgE to recipients mast cells and basophils could not be ruled out (114). 

Passive Immunotherapy - In passive immunotherapy, immune modalities are given to a tumor host which will enable it to more effectively reject its tumor. These modalities may consist of activated mononuclear cells, extracts of sensitized lymphocytes or serological factors such as specific antibodies or complement. Lymphocytes, macrophages or thymocytes may be transferred in passive immunotherapy. 

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