Lymphocyte homing, selectins

Selectins Play Key Roles in Inflammation in Lymphocyte Homing... 

CD62L L selectin, LECAM-1. Mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue, leukocyte rolling on activated endothelium at inflammatory sites. 

Hemmerich S, Bistrup A, Singer MS, van Zante A, Lee JK, Tsay D, Peters M, Car-minati JL, Brennan TJ, Carver-Moore K, Leviten M, Puentes ME, Ruddle NH, Rosen SD. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity 2001 15 237-247. 

Mitoma J, Bao X, Petryanik B, Schaerh P, Gauguet JM, Yu SY, Kawashima H, Saito H, Ohtsubo K, Marth JD, Khoo KH, von Andrian UH, Lowe JB, Fukuda M. Critical functions of A-gJycans in L-selectin-mediated lymphocyte homing and recruitment. Nat Immunol 2007 8 409 18. 

Arbones, M.L., Ord, D.C., Key, K. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity, 1994, I, 247-260. 

A. Selectins are a family of so-called homing receptors that include P-selectin (platelet selectin), E-se-lectin (endothelial cell selectin), and L-selectin (leukocyte selectin). They are involved in the homing of lymphocytes to lymph nodes. Selectins support leukocy te-endotheUal cell and leukocyte-platelet adhesion and mediate the migration of neutrophil granulocytes in developing inflammatory reactions. Selectins bind at least three broad categories of natural or synthetic carbohydrates [195]. 

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