Lymphoblastic MOLT-4 cells

Schwartz GK, Arkin H, Holland JF, Ohnuraa T (1991) Protein kinase C activity and multidrug resistance in MOLT-3 human lymphoblastic leukemia cells resistant to trimetrexate. Cancer Res 51 55-61... 

A single human lymphoblast (MOLT-3) was retained by a weir (5 p.m) in a PDMS-glass chip. This cell channel was separated from another channel containing SDS lysing solution by a gas bubble (introduced by a thermopneumatic actuator). Removal of the gas bubble initiated the liquid mixing, and cell lysis occurred [842],... 

TABLE 20.8 Inhibitory Effects of Nucleoside Derivatives on Human T-lymphoblast Molt/4F and MT4 Cells ... 

Moreover, cyanidin 3-O-rutinoside (5) also induced apoptosis in other human leukemia cell lines and human lymphoma cell lines such as MOLT-4 cells of human acute lymphoblastic leukemia cell line, Daudi cells of human... 

MOLT-3 human T-lineage acute lymphoblastic leukemia cell line... 

In order to evaluate the in vitro antitumor activity of the prodrugs, compounds 20 and 21 were incubated at varied concentrations with human T-lineage acute lymphoblastic leukemia MOLT-3 cells in the presence or absence of ImM of PGA. The data from the cell proliferation assays are presented in Fig. 5.15. 

Cecchinato V, Chiaramonte R, Nizzardo M, Cristofaro B, Basile A, Sherbet GV, Comi P. 2007. Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells. Biochem Pharmacol 74 1568-1574. 

C9H14N4O4 242.234 Antineoplastic nucleoside. Shows significant activity against mouse leukaemia L1210, human T-cell acute lymphoblastic leukaemia Molt 4F and HeLa cells in vitro. Log P -3.03 (calc). Resistant to cytidine deaminase. 

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