Lyme hepatitis

In isolated cases, pronounced Lyme hepatitis develops. The pathogen is often identifiable in liver cells and sinusoids. Treatment consists of doxycycline or erythromycin. 

Haemophilus influenzae type b conjugate and hepatitis B vaccine he -maw-fil-us in-flu-en -zah kon-jew -gate hep -ah-tie -tus bee-vak -seen Lyme disease vaccine (recombinant OspA) lime-vak -seen... 

Available killed vaccines include acellular pertussis, anthrax, botulism, cholera, diptheria, hepatitis A, hepatitis B, Haemophilus influenzae type b (Hib), influenza, Lyme disease, meningococcus, pertussis, plague, pneumococcus, polio, rabies, tetanus, typhoid, and typhoid VI. 

Doxycydine (Adoxa, Periostal-, Oracea, Vibramycin, Vibra-Tabs) [Anribiotic/Tetracycline] Uses Broad-spectrum antibiotic acne vulgaris, uncomplicated GC, Chlamydia sp, PID, Lyme Dz, skin Infxns, anthrax, malaria prophylaxis Action Tetracycline bacteriostatic X- protein synth Dose Adults. 100 mg PO ql2h on 1st d, then 100 mg PO daily bid or 100 mg IV ql2h acne daily dosing, Chlamydia 7d, Lyme Dz 14—21 d, PID 14 d Peds >8 y 5 mg/kg/24 h PO, to a max of 200 mg/d - daily-bid Caution [D, +] Hepatic impair Contra Children <8 y, severe hepatic dysfxn Disp Tabs, caps, syrup, susp, inj SE D, GI disturbance, photosens Interactions T Effects OF digoxin, warfarin 1 effects W/ antacids, Fe, barbiturates, carbamazepine, phenytoins, food 4-effects OF penicillins EMS Monitor for signs of electrolyte disturbances and hypovolemia d/t D monitor for S/Sxs of super Infxn T risk of photosensitivity Rxns antibiotic of choice for the Tx and prophylaxis of anthrax exposure expired tetracyclines have been known to cause nephrotox OD May cause adverse GI effects symptomatic and supportive... 

Chavanet, P., Pillon, D., Lancon, J.P., Waldner-Combernoux, A., Mar-inge, E., Portier, H. Granulomatous hepatitis associated with Lyme disease. Lancet 1987 11 623 -624... 

Killmann, H., Lind, P., Stanek, G. Akute Hepatitis bei Lyme — Bor-reUose. Wien. Med. Wschr. 1987 14 343-346... 

Immunology/infectious diseases Diseases affecting the defense mechanisms of the body. Studies in this area include AIDS, auto-immune diseases, bacterial infections, chronic fatigue syndrome, common cold, genital herpes, genital warts, hepatitis, HIV infections, immunosuppressive, influenza, lyme disease, meningitis, parasite and protozoan infections, strep throat, vaccines, viral infections, and others. 

Biohazard level 2. Hepatitis B, hepatitis C, influenza, Lyme disease, Salmonella, scrapie. 

Hypersensitivity. Hypersensitivity reactions, considered to be vaccine-related based on the timing and specificity of the reactions, were reported to the United States Vaccine Adverse Event Reporting System (VAERS) following vaccination for Lyme disease and subsequently evaluated (Burmester et al., 1995 Lathrop et al., 2002). Other reported immune system-related events to vaccines included rheumatoid arthritis, immune system disorders, detection of antinuclear antibodies, lupus syndrome, and lymphocytosis (Zhou et al., 2003). These were very rare events, with each condition comprising 0.2% or fewer of the total reports. Anaphylactic responses to vaccines were also rare and were estimated at less than one case per miUion administered vaccine doses (Bohlke et al., 2003). A number of studies evaluated anaphylactic responses to the measles-mumps-rubella (MMR), hepatitis B, diphtheria or tetanus vaccines with similar findings (Dobson et al., 1995 D Souza et al., 2000 Patja et al, 2000 Pool et al., 2002). However, some of the vaccine-induced hypersensitivity reactions are attributed to components of the formulation, such as gelatin or egg, rather than the antigen itself (Patja et al., 2001 Pool et al., 2002). 

Hepatitis B vaccine Prevention of hepatitis B Lyme disease vaccine Prevention of Lyme disease... 

Recombinant subunit vaccine is where DNA of a pathogen is inserted into a cell or organism. The cell or organism then produces massive quantities of the pathogen that are used in place of the whole pathogen. Examples are hepatitis B and LYMErix for Lyme disease. 

Hiere have been no major developments in recombinant vaccine production since the hepatitis B vaccine. Recombinant vaccines were produced against Lyme disease and rotavirus but have been subsequently withcbawn from the market. Recendy, an oral diolera vaccine (Dukoral) based on mixture on inactive cholera bacteria and a cholera toxin B subtmit produced by recombinant technology has been launched. 

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