Recombinant luteinizing hormone

Loumaye EEuropean Recombinant LH Study Group. Human recombinant luteinizing hormone is as effective as, but safer than, urinary human chorionic gonadotropin in inducing final follicular maturation and ovulation in in vitro fertilization procedures results of a multicenter double-blind study. J Clin Endocrinol Metab 2001 86(6) 2607-18. 

FSH is a member of a superfamily of proteins, all structurally related. which includes luteinizing hormone (LH), chori->inlc gonadotropin, and thyroid-stimulating hormone (TSH). It is u heterodimer, the a subunit contains 92 amino acids, and the subunit contains 111 amino acids. The protein IS rather heavily glycosylated and has a molecular mass of approximately 33 kDa. The traditional source for isolation t l FSH was postmenopausal urine, which provided a preparation that was less than 3% pure and wa.s signiricantly contaminated by LH. The recombinant human FSH (rhFSH) is produced in a mammalian cell line, the CHO. 

Danila, D. C. Schally, A. V Nagy, A. Alexander, J. M. Selective induction of apoptosis by the cytotoxic analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone. Proc. Natl. Acad. Sci. USA 1999, 96, 669-673. 

G. De Placido, C. Alviggi, A. Perino, I. Strina, F. Lisi, A. Fasolino, R. De Palo, A. Ranieri, N. Colacurci, A. MoUo and on behalf of the Italian Collaborative Group on Recombinant Human Luteinizing Hormone, Hum. Reprod., 2005, 20, 390. 

Veldhuis, J.D., and Iranmanesh, A. (2004) Pulsatile intravenous infusion of recombinant human luteinizing hormone under acute gonadotropinreleasing hormone receptor blockade reconstitutes testosterone secretion in young men. Journal of Clinical Endocrinology and Metabolism, 89,4474-4479. 

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