Lupeol palmitate

Jatropha podagrica Hooker San Hu You Tong (stem bark) Tetramethylpyrazine, steroids, n-hexacosane, beta-amirine, lupeol palmitate, beta-sitosterol, rutin, flavonoids, quercetin, apigenin, vitexin, isovitexin.57-207 208 This herb is toxic. Detoxicant, hypotensive, neuromuscular and cardiovascular actions, antibacterial, relieve swelling, pain, externally treat snakebite, infection. 

Lupeol palmitate (= Lupeol hexadecanoic acid ester) (lupane triterpene FA ester) Semi-synthetic from Lupeol CHY (> 50 pM), TRY (6 pM) [10 pM] [106]... 

Lupeol palmitate (= Lupeol hexadecanoic Semi-synthetic from Lupeol PKA (9) [4] (CABPase, CHY, TRY) [AI]... 

Lupeol palmitate ( = Lupeol hexadecanoic acid ester)] (lupane triterpene FA ester)... 

Among five triterpenoids isolated from Calendula officinalis flowers, P-amyrin (119), faradiol (232), i /-taraxasterol (238), taraxasterol (239), and lupeol (238), the diol 232 was the most active. It showed a dose-dependent effect with a potency that equals that of indomethacin (5) in the topical anti-inflammatory assay with croton oil [33]. Esterification at C-3 of 232 with a fatty acid reduced the activity by more than 50% [33] consistent with our observation in the TPA-induced assay described above. The anti-inflammatory properties, as determined by croton oil-induced edema of mouse ear, of faradiol-3-O-myristate (233) and its 3-O-palmitate (234), the main components of lipophilic extracts of C. officinalis flowers, were shown to be contribute significantly to the pronounced antiphlogistic activity of the lipophilic extracts of C. officinalis flowers [34]. 

Heliantriol C 3-O-myristate (= Taraxast-20-ene-3P,16 3,22a-triol 3-O-myristate) (triterpene) Heliantriol C 3-O-palmitate (= Taraxast-20-ene-3 3,160,22a-triol 3-O-palmitate) (triterpene) Lupeol (= Fagasterol Monogynol B fl-Viscol) (lupane triterpene)... 

The hydrophobic triterpenoids a-amyrin and lupeol (both having a 3-hydroxy as the only polar group) and their palmitate and linoleate esters are similarly potent and relatively selective inhibitors (IC50 = 4-9 pM). These triterpenoids are in vivo anti-inflammatory agents, and their relatively selective PICA inhibition activity suggests that PKA could be involved in the inflammatory process although the responsible mechanisms are not yet clear [90]. 

Sterols and triterpenes (P-amyrin, P-sitos-terol, lupeol, stigmasterol, viscin, hetulinic acid, oleanolic acid, and ursolic acid), ° fatty acids (oleic, linoleic, palmitic, and stearic acids),and an acyclic monoterpene glycoside (2,6-dimethylocta-2,7-diene-1,6-diol 4-0-apiosylglucoside) have recently been isolated from mistletoe. ... 

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