Antiphlogistic activities

SRI 29 Breu, W., M. Hagenlocher, K. Redl, G. Tittel, F. Stadler, and H. Wagner. Antiphlogistic activity of an extract from Sabal serrulata fruits prepared by supercritical carbon dioxide/in vitro inhibition of the cyclooxygenase and 5-lipoxygenase metabolism. Arzneim-forsch 1992 42(4) 547-551. 

Among five triterpenoids isolated from Calendula officinalis flowers, P-amyrin (119), faradiol (232), i /-taraxasterol (238), taraxasterol (239), and lupeol (238), the diol 232 was the most active. It showed a dose-dependent effect with a potency that equals that of indomethacin (5) in the topical anti-inflammatory assay with croton oil [33]. Esterification at C-3 of 232 with a fatty acid reduced the activity by more than 50% [33] consistent with our observation in the TPA-induced assay described above. The anti-inflammatory properties, as determined by croton oil-induced edema of mouse ear, of faradiol-3-O-myristate (233) and its 3-O-palmitate (234), the main components of lipophilic extracts of C. officinalis flowers, were shown to be contribute significantly to the pronounced antiphlogistic activity of the lipophilic extracts of C. officinalis flowers [34]. 

Brue, W., and M. Hagenlocher, et al. "Antiphlogistic Activity of an Extract from Sabal [sic] serrulata Fruits Prepared by Supercritical Carbon Dioxide." Arzneim-Forsch Drug Report 42 54751, 1992. 

Nifemazone had good antiphlogistic activity, showing prompt onset and sustained action especially in albumin-induced edema. It had antipyretic and analgesic effects similar to aminophenazone and phenylbutazone vide infra) but much less toxic than the latter. 

Antiphlogistic activity of polysaccharides AS3 and AS4 of Achyrocline satureioides in the rat paw carragenan induced edema model. 1 h after s.c injection of 0.05 ml1% carragenan sol. 3 mg each of A53 and A54/ml were i.v. injected. The volumes were recorded by plethys-mometry. Ref. compound indometacin (10 mg/kg). 

---