Lungs antioxidant status

Kelly FJ, Mudway I, Blomberg, A., Frew AJ and SandstrOm T. Altered lung antioxidant status in patients with mild asthma. The Lancet 354 (1999) 482-483. 

Table 2. Strategies for elevating the antioxidant status of the lung.

Numerous reports of elevated concentrations of lipid [57,58], protein [57,58] and DNA [54] oxidation products in CF patients have now been published. Importantly, oxidative stress is not present in all CF patients at all times. Oxidative stress, like the recurring infections, is probably cyclic. Importantly, antioxidant status tends to decrease with age in CF [58], hence older CF patients are particularly susceptible to renewed cycles of pulmonary inflammation. It is tempting to speculate that it is this oxidant/antioxidant imbalance that is responsible, in part, for their decline in lung function with advancing age. The reason for the fall in antioxidant status in CF is not clear, however decreased compliance in taking vitamin supplements may play a role. Alternatively, it is conceivable those repeated cycles of pulmonary inflammation, and associated oxidative stress, also contributes to the decline in antioxidant status. Whatever the exact cause, it is probable that the worsening antioxidant status of the CF adolescent contributes to their deteriorating clinical circumstances. 

Ozone-induced lung damage Male F344 rats Decreased inflammatory response combined with increased antioxidant status... 

Wistar rats administered capsaicin (i.p. 3 mg/kg body weight) for three consecutive days showed a reduction of oxidative stress measured as malondialdehyde in the liver, lung, kidney, and muscle [128]. From this study, it is hypothesized that capsaicin can be a potent antioxidant even when consumed for a short period. The influence of capsaicin on the antioxidant status of red blood cells and liver tissue in hyperlipidemic rats is reported [129]. Capsaicin (0.015 %) in the diet which produced the hypotriglyceridemic effect was also effective in reducing the oxidant stress, which was indicated by countering of the depleted antioxidant molecules and antioxidant enzymes in erythrocytes and liver, and decreasing of the elevated lipid peroxide content. The beneficial influence of capsaicin on the antioxidant status of red blood cells and liver in induced hypercholesterolemic rats is also evidenced [130]. The depletion in intracellular thiols and GSH in red blood cells under hypercholesterolemic situation was effectively countered by dietary (0.015 %)... 

Nicotine has been identified as the main risk factor for limg diseases. The protective effect of curcumin on blood antioxidant status during nicotine-induced toxicity was established in rats (Kalpana and Menon 2004). Administration of curcumin significantly lowered the lipid peroxidation and enhanced the antioxidant status. Curciunin exerts its protective effect against nicotine-induced lung toxicity by modulating the extent of lipid peroxidation and augmenting antioxidant defense system. 

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