Lung volume definition

The inhaled air volume (V in L) depends on the extent of chest enlargement. During normal breathing, the inhaled and exhaled volumes (tidal volume) are only part of the total lung volume [8,21]. The different parameters that describe pulmonary ventilation are shown in Figure 3.2. Table 3.1 presents a definition of the different parameters. Normal adults have a tidal... 

Nestle U, Schaefer-Schuler A, Kremp S, Groeschel A, Hellwig D, Rube C, Kirsch CM (2007) Target volume definition for (18)F-FDG PET-positive lymph nodes in radiotherapy of patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging 34 453-462... 

Greco C, Rosenzweig K, Cascini GL et al (2007) Current status of PET/CT for tumour volume definition in radiotherapy treatment planning for non-small cell lung cancer (NSCLC). Lung Cancer 57 125-134... 

Dead space. Anatomical dead space is equal to the volume of the conducting airways. This is determined by the physical characteristics of the lungs because, by definition, these airways do not contain alveoli to participate in gas exchange. Alveolar dead space is the volume of air that enters unperfused alveoli. In other words, these alveoli receive airflow but no blood flow with no blood flow to the alveoli, gas exchange cannot take place. Therefore, alveolar dead space is based on functional considerations rather than anatomical factors. Healthy lungs have little or no alveolar dead space. Various pathological conditions, such as low cardiac output, may result in alveolar dead space. The anatomical dead space combined with the alveolar dead space is referred to as physiological dead space ... 

Tidal breath To demonstrate the compliance of the lung during tidal ventilation, draw the dotted curve. This curve is similar in shape to the first but the volume change is smaller. It should start from, and end at, the FRC by definition. 

Van de Steene J, Linthout N, de Mey J, Vinh-Hung V, Claassens C, Noppen M, Bel A, Storme G (2002) Definition of gross tumor volume in lung cancer inter-observer variability. Radiother Oncol 62 37-49... 

Patterson GM, Wilson S, Whang JL, et al. Physiologic definitions of obUterative bronchiolitis in heart-lung and double lung transplantation a comparison of the forced expiratory flow between 25% and 75% of the forced vital capacity and forced expiratory volume in one second. J Heart Lung Transplant 1996 15 175-181. 

This new volume edited by Steven Albelda brings to the readership the most recent research and clinical outcomes pertaining to gene therapy in lung disease. As is quickly apparent, no definitive or even imminent cure is described, but a panoramic view of what may be expected is presented. The reader will be left with the strong feeling that we are close to something that has the potential to be veiy important, especially for some patients. 

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