Lung resistance protein

Lung resistance protein Lung resistance protein (LRP) is expressed in normal human bronchial epithelium (NHBE) as well as in other tissues potentially exposed to toxins [104], LRP was reported to be expressed in both Calu-3 cells [105] and 16HBE14o- model [70], However, the role of LRP in different cellular locations is not clear to date. 

Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, van der Valk P, Scheper RJ (1996) Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am J Pathol 148(3) 877-887. 

Finally, a protein has been identified that is unique from the previously discussed ABC proteins. This protein, called lung resistance protein or major vault protein, has a molecular weight of 110 kD and is found not in the cell membrane but rather the nuclear membrane or the cytoplasm. The role of this protein is to prevent the drug from accessing the nucleus by trapping the drug in vesicles called vaults. The vaults then shuttle... 

Sugawara I, Akiyama S, Scheper RJ, Itoyama S. Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDRl and MRP. Cancer Lett 1997 112 23-31. 

Pohl G, Filipits M, Suchomel RW, Stranzl T, Depisch D, Pirker R. Expression of the lung resistance protein (LRP) in primary breast cancer. Anticancer Res 1999 19 5051-5056. 

The different mechanisms of MDR observed in tumor celk can be classified into (a) P-glycoprotein-mediated (165,197,198) (b) multidrug resistance protein (MRP)-mediated (199,2(X)) (c) lung resistance protein (LRP)-mediatcd (201) and (iv) topoisomerase Il-mediated (at-ME)R) (143,162,165,167,196). By fw. the most important resistance mechanism is that mediated by PI 70, a member of the transmembrane. mul-tidn resistance exporter protein family (165,197,198). 

Ehrhardt C, Kneuer C, Laue M, Schaefer UF, Kim KJ, Lehr CM (2003) 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1. Pharm Res 20(4) 545-551. 

Lehmann T, Torky AR, Stehfest E, Hofmann S, Foth H (2005) Expression of lung resistance-related protein, LRP, and multidrug resistance-related protein, MRP1, in normal human lung cells in long-term cultures. Arch Toxicol 79(10) 600-609... 

Yoh K, Ishii G, Yokose T, Minegishi Y, Tsuta K, Goto K, Nishiwaki Y, Kodama T, Suga M, Ochiai A. Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer. Clin Cancer Res 2004 10 1691-1697. 

Uozaki, H., Horiuchi, H., Ishida, T., Lijima, T Imamura, T., and Machinami, R. (1997) Overexpression of resistance-related proteins (metallothioneins, glu-tathione-S-transferase, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Cancer 79, 2336-2344. 

Kawabata, S., Oka, M., Shiozawa, K., Tsukamoto, K., Nakatomi, K., Soda, H., Fukuda, M., Ikegami, Y. et al. (2001) Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. Biochemical and Biophysical Research Communications,... 

BCRP (also known as ABCG2) is a half ABC transporter. It is sometimes known as mitoxantrone resistance protein (MXR) because of its elevated expression in many cancer cell lines selected with mitoxantrone [54]. BCRP was first identified in breast cancer, but it is also found in several normal tissues, including placenta, liver canaliculi, small intestine, colon, the bronchial epithelial layer in the lung, and endothelial cells [55]. Its level is also elevated in other cancer types. For instance, an analysis of 150 untreated tumors with immuno-histochemical technique demonstrated a high incidence of BCRP overexpression particularly in tumors of gastrointestinal origin [56]. Elevated BCRP level is consistently associated with the phenotype that includes strong resistance to mitoxantrone, moderate resistance to anthracyclines, and sensitivity to... 

ABC, ATP-binding cassette AML, acute mylogenous leukemia NSCLC, non-small-cell lung cancer NSAIDs, non-steroidal anti-inflammatory drugs BCRP, breast cancer resistance protein MDRl, multidrug resistance 1 MRP, multidrug resistance-associated proteins P-gp, P-glycoprotein. 

Zhou J, Higashi K, Ueda Y, Kodama Y, Guo D, Jisaki F et al. Expression of multidrug resistance protein and messenger RNA correlate with (99m)Tc-MIBI imaging in patients with lung cancer. J Nucl Med 2001 42 1476-1483. 

Yeh JJ, Hsu NY, Hsu WH, Tsai CH, Lin CC and Liang JA. Comparison of chemotherapy response with P-glycoprotein, multidrug resistance-related protein-1, and lung resistance-related protein expression in untreated small cell lung cancer. Ltmg 2005 183 177-183. 

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