Lung resistance

Measurement of rate, tidal volume and lung resistance and compliance in anaesthetized animals... [Pg.740]

The pressure change per unit change in volume (cmH20.ml 1 orkPa.l ). Lung resistance... [Pg.142]

Total resistance = Chest wall resistance + lung resistance... [Pg.142]

Lung resistance protein Lung resistance protein (LRP) is expressed in normal human bronchial epithelium (NHBE) as well as in other tissues potentially exposed to toxins [104], LRP was reported to be expressed in both Calu-3 cells [105] and 16HBE14o- model [70], However, the role of LRP in different cellular locations is not clear to date. [Pg.244]

Ehrhardt C, Kneuer C, Laue M, Schaefer UF, Kim KJ, Lehr CM (2003) 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1. Pharm Res 20(4) 545-551. [Pg.253]

Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, van der Valk P, Scheper RJ (1996) Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am J Pathol 148(3) 877-887. [Pg.255]

Lehmann T, Torky AR, Stehfest E, Hofmann S, Foth H (2005) Expression of lung resistance-related protein, LRP, and multidrug resistance-related protein, MRP1, in normal human lung cells in long-term cultures. Arch Toxicol 79(10) 600-609... [Pg.280]

Mouse 8 Whole body 1,500 5 min Lung resistance increased up to 3 d after exposure. Responses to methacholine LOAEL 1500 Demnatt et al. [Pg.136]

Uozaki, H., Horiuchi, H., Ishida, T., Lijima, T Imamura, T., and Machinami, R. (1997) Overexpression of resistance-related proteins (metallothioneins, glu-tathione-S-transferase, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Cancer 79, 2336-2344. [Pg.13]

The effects of intratracheal instillation of selenium on pulmonary function may be dependent on the form in which it is supplied (Nonavinakere et al. 1999). Instillation of 0.06 mg selenium/100 g body weight as selenium dioxide produced a significant decrease in respiratory rate and a significant increase in lung resistance compared with controls. Instillation with 0.06 mg selenium/110 g body weight as seleno-L-methionine also produced a decrease in respiratory rate and an increase in lung resistance, but the values were not significantly different from controls. [Pg.47]

Finally, a protein has been identified that is unique from the previously discussed ABC proteins. This protein, called lung resistance protein or major vault protein, has a molecular weight of 110 kD and is found not in the cell membrane but rather the nuclear membrane or the cytoplasm. The role of this protein is to prevent the drug from accessing the nucleus by trapping the drug in vesicles called vaults. The vaults then shuttle... [Pg.369]

Sugawara I, Akiyama S, Scheper RJ, Itoyama S. Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDRl and MRP. Cancer Lett 1997 112 23-31. [Pg.242]

Pohl G, Filipits M, Suchomel RW, Stranzl T, Depisch D, Pirker R. Expression of the lung resistance protein (LRP) in primary breast cancer. Anticancer Res 1999 19 5051-5056. [Pg.242]

Yeh JJ, Hsu NY, Hsu WH, Tsai CH, Lin CC and Liang JA. Comparison of chemotherapy response with P-glycoprotein, multidrug resistance-related protein-1, and lung resistance-related protein expression in untreated small cell lung cancer. Ltmg 2005 183 177-183. [Pg.637]

The different mechanisms of MDR observed in tumor celk can be classified into (a) P-glycoprotein-mediated (165,197,198) (b) multidrug resistance protein (MRP)-mediated (199,2(X)) (c) lung resistance protein (LRP)-mediatcd (201) and (iv) topoisomerase Il-mediated (at-ME)R) (143,162,165,167,196). By fw. the most important resistance mechanism is that mediated by PI 70, a member of the transmembrane. mul-tidn resistance exporter protein family (165,197,198). [Pg.597]

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