Lung cancer surgical

Kobayashi and colleagues evaluated endogenous secretory receptor for advanced glycation end products in 182 non-small cell lung cancer surgical specimens. The authors found that endogenous secretory receptor... 

Surgical resection of the tumor is the mainstay of treatment in early-stage non-small cell lung cancer and produces the longest survival rates. 

The earliest combination chemotherapy and radiation trials in nonsmall-cell lung cancer included cisplatin and 5-fluorouracil and concurrent radiation therapy and found survival results comparable to those for sequential chemotherapy and radiation or to daily cisplatin and radiation therapy without surgery (119,121). Phase II studies of stage Ilia and Illb nonsmall-cell lung cancer patients treated with the combination of cisplatin with etoposide and 5 -fluorouracil and either single daily radiation fractionation or twice daily radiation fractionation prior to surgery produced similar clinical results (119,121). Complete surgical resection was accomplished in 70% of the patients, the median survival was 22 mo and the 2-yr survival rate was 45%. 

Rusch VW, Albain KS, Crowley J J, et al. Surgical resection of stage Ilia and stage Illb non-small cell lung cancer after concurrent induction chemoradiotherapy. J Thoracic Cardiovasc Surg 1993 105 97-106. 

Lad TE. Post-surgical therapy in stage I, II, III A non-small cell lung cancer [Review], Hematology-Oncology Clinics of North America 1990 4 1111-1119. 

Surgery can cure lung cancer, but only one in five patients are suitable for this treatment. If the tumor has not spread outside the chest and does not involve vital structures such as the liver, then surgical removal may be possible, but only if the patient does not also have severe bronchitis, heart disease, or other illnesses. Small cell lung cancer is treated with chemotherapy. Non-small cell cancer may be treated with radiotherapy and chemotherapy (as part of a research trial) or with supportive care. Radiotherapy is either radical or palliative. ... 

Mollo F, Piolatto G, Beilis D, et al. 1990. Asbestos exposure and histologic cell types of lung cancer in surgical and autopsy series. Int J Cancer 46 576-580. 

Rosell R, Li S, Skacel Z, et al. Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients. Oncogene 1993 8 2407-2412. 

Deslauriers J, Gregoire J. Surgical ther y for early non-small cell lung cancer. Chest 2000 177(Suppl 4) 104S-109S. 

Lee Y-C, Wu C-T, Kuo S-W, et al. Significance of extranodal extension of regional lymph nodes in surgically resected nonsmall cell lung cancer. Chest. 2007 131 993-999. 

Nick O Tyne. Surgical resection of the primary lung cancer with an J attempt at cure was justified in Nick O Tyne, who had a good prognosis with a Ti,Ni,Mo staging classification preoperatively. Without some evidence of spread to the central nervous system at that time, a preoperative CT scan of the brain would not have been justified. This conservative approach would require scanning of all of the potential sites for metastatic disease from a non-small cell cancer of the lung in all patients who present in this way. In an era of runaway costs of health care delivery, such an approach could not be considered cost-effective. 

T. Koike, M. Terashima, T. Takizawa, et al. (1999). The influence of lung cancer mass screening on surgical results. Lung Cancer, 24, 75-80. 

B.J. Flehinger, M. Kimmel, M.R. Melamed (1992). The effect of surgical treatment on survival from early lung cancer The impact of screening. Chest, 101, 1013-1018. 

FIGURE 8.3 PLS-DA score plot of the first two latent variables (74% and 18% of explained variance respectively). Classes are labeled as—(1) lung cancer, (2) controls, and (3) postsurgery. Arrows indicate the two patients measured before and after the surgical treatment. 

Duarte IG, Bufkin BL, Pennington MF, et al. Angiogenesis as a predictor of survival after surgical resection for stage I non-small-cell lung cancer. J Thorac Cardiovasc Surg 1998 115 652-658 discussion 658-659. 

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