Surface modified nanoparticles

The synthetic route for making the Janus nanoparticles first consists in the emulsion polymerization of styrene in the presence of silica nanoparticles surface-modified by polymerizable groups. Snowman-like hybrid nanostructures are thus obtained with 85% yield in which the... 

Vandorpe, J., Schacht, E., Stolnik, S., et al. (1996). Poly(organo phosphazene) nanoparticles surface modified with poly(ethylene oxide). Biotechnol. Bioengineer, 52, 89-95. 

M.C. Ilium, L. Long circulating biodegradable 68. poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer. Biomaterials 1997, 18, 1147-1152. 69. 

Cobalt nanoparticles (surface modified with L-cysteine ethyl ester) ethanol wet are available as 10mn black powder (wet with EtOH) which is best used within 3 months. The material can be easily transferred into stable aqueous suspensions, and can be used as a starting material for surface modifications (e.g. dextran coating) or the preparation of magnetic polymer microspheres. 

Nakayama, N. H ashi, T. Preparation of Ti02 nanoparticles surface-modified by both carboxylic acid and amine Dispersibility and stabilization in organic solvents. Coll. Surf. A, 2008, 317, 543-550. 

Zahr AS, Davis CA, Pishko MV. Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol). Langmuir 2006 22 8178-85. 

PS-TiOa nanohybrid particles were synthesized in high yield via in-situ polymerization of styrene in the presence of Ti02 nanoparticles surface-modified with 3-(trimethoxysilyl)-propylmethacrylate (MPS) [173]. The encapsulation of nano-Ti02 by PS via mini-emulsion polymerization was also reported. In this case, polybutene-succinimide pentamine was used as stabilizer at the oil-water interface [174-176]. 

Gref R, Luck M, Quellec P, Marchand M, Dellacherie E, Hamisch S, et al. Stealth corona-core nanoparticles surface modified by polyethylene glycol (PEG) influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerfaces October 1, 2000 18(3 ) 301-13. 

Xue X, Wang J, Mei L, Wang Z, Qi K, Yang B. Recognition and enrichment specificity of Fe304 magnetic nanoparticles surface modified by chitosan and Staphylococcus aureus enterotoxins A antiserum. CoUoids Surf B Biointerfaces. 2012 103 107-13. 

Dzunuzovic, E. S., J. V. Dzunuzovic, T. S. Radoman et al. 2013. Characterization of in situ prepared nanocomposites of PS and Ti02 nanoparticles surface modified with alkyl gallates Effect of alkyl chain length. Polym. Compos. 34 399-407. 

Figu re 4.8 Flow cytometry analysis of silica nanoparticles surface-modified with proteins. MPMS nanoparticles (a, c) and TEOS nanoparticles (b, d) modified with GFP (a, b) or phycoerythrin-conjugated streptavidin... 

Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H., and Lehr, C.M., Surface modified silica-nanoparticles can enhance transfection in vitro a novel class of non-viral DNA vectors, Bioconjugate Chemistry, 2000, 11, 926-932. 

Oxide semiconductor nanoparticles such as ZnO were surface-modified by Dutta et al. using a different approach [76]. They described the design and fabrication of... 

Fluorescent silica nanoparticles, called FloDots, were created by Yao et al. (2006) by two synthetic routes. Hydrophilic particles were produced using a reverse micro-emulsion process, wherein detergent micelles formed in a water-in-oil system form discrete nanodroplets in which the silica particles are formed. The addition of water-soluble fluorescent dyes resulted in the entrapment of dye molecules in the silica nanoparticle. In an alternative method, dye molecules were entrapped in silica using the Stober process, which typically results in hydrophobic particles. Either process resulted in luminescent particles that then can be surface modified with... 

Based on well established silica chemistry, the surface of silica nanomaterials can be modified to introduce a variety of functionalizations [3, 11, 118]. The toxicity of surface-modified nanomaterials is largely determined by their surface functional groups. As an example, Kreuter reported that an apolipoprotein coating on silica nanoparticles aided their endocytosis in brain capillaries through the LDL-receptor [122-124]. Overall, silica nanomaterials are low-toxicity materials, although their toxicity can be altered by surface modifications. 

Deposition-Precipitation (DP) of Gold Precursor on Surface-Modified Amorphous Silica. The gold nanoparticles were deposited on the above surface-modified amorphous silicas by using the same process as that given in Section 5.2.2.2. 

Figure 29. Fiuman osteoblast-like MG 63 cells in cultures on material surfaces modified with carbon nanoparticles. A fullerene Cgo layers deposited on carbon fibre-reinforced carbon composites (CFRC), B fullerene C o layers deposited on microscopic glass coverslips, C terpolymer of polytetrafluoroethylene, polyvinyldifluoride and polypropylene, mixed with 4% of single-wall carbon nanohorns, D the same terpolymer with high crystalline electric arc multi-wall nanotubes, E diamond layer with hierarchically organized micro- and nanostmcture deposited on a Si substrate, F nanocrystalline diamond layer on a Si substrate. Standard control cell culture substrates were represented by a PS culture dish (G) and microscopic glass coverslip (FI). Immunofluorescence staining on day 2 (A) or 3 (B-Fl) after seeding, Olympus epifluorescence microscope IX 50, digital camera DP 70, obj. 20x, bar 100 pm (A, C, D, G,H)or 200 pm (B, E, F) [16].

Liversidge G, Cimdy K, Bishop J, Czekai D, Sterling Drug, Inc. Surface modified drug nanoparticles. US Patent 5 145 684... 

Chemically prepared colloidal gold nanoparticles were immobilized as a submonolayer on Au(lll) surface modified with self-assembled monolayers (SAMs) of 4-aminothiophenol [14]. This submonolayer of Au nanoparticles was subsequently characterized using STM. 

Fig. 10 (a, b) Schematic mechanism demonstrated for a reflective color M-paper with magnetically controllable characteristics, (c, d) The intensity of magnetic field dependence on the reflection spectra of chiral nematic mixtures doped with magnetite nanoparticles that are surface modified with oleic acid and a chiral pyridine-based dopant, as well as photographs of both formulations before and after a magnetic field of 1,000 GS was applied (see photograph insets above) [364], (Copyright 2010, Taylor Francis)... 

Very recently Beer and co-workers have developed a surface-enhanced optical anion sensor based on gold nanoparticles [78]. Dodecanethiol-stablised gold nanoparticles were modified by ligand substitution with a disulphide-substituted zinc porphyrin 113 to provide 30 and 80 receptors per nanoparticle. Titration of both the free receptor and the modified nanoparticles with various... 

In applications where self-polishing is not possible, the combination of a microbe-repelling surface and a release system seems to be desirable. One example of a design for such a surface is shown in Fig. 8. The depicted coating is based on a hydrophilic polymer network that contains polyethyleneimine crosslinkers, which are capable of selectively taking up silver ions and acting as a template for silver nanoparticles [90], This reloadable co-network was surface-modified with PEG,... 

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