Locus coeruleus neurons

Aston-Jones, G, Shipley, MT, Chouvet, G et al. (1991) Afferent regulation of locus coeruleus neurons anatomy, physiology and pharmacology. Prog. Brain Res. 88 47-73. 

Aston-Jones, G, Rajkowski, J, Kubiak, P and Alexinsky, T (1994) Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task. J. Neurosci. 14 4467 480. 

Rajkowski, J, Kubiak, P, Ivanova, S and Aston-Jones, G (1998) State-related activity, reactivity of locus coeruleus neurons in behaving monkeys. Adv. Pharmacol. 42 740-744. 

Rasmussen, K and Jacobs, BE (1986) Single unit activity of locus coeruleus neurons in the freely moving cat IE Conditioning and pharmacological studies. Brain Res. 371 335-344. 

Noradrenaline (norepinephrine) brainstem locus coeruleus neurons... 

Jones, B. E. (1991b). The role of noradrenergic locus coeruleus neurons and... 

Pieribone, V. A., Xu, Z. Q., Zhang, X. et al. (1995). Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience 64, 861-74. 

Aston-Jones, G. Bloom, F. E. (1981). Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J. Neurosci. 1, 876-86. 

Egan, T. M. North, R. A. (1986). Actions of acetylcholine and nicotine on rat locus coeruleus neurons in vitro. Neuroscience 19, 565-71. 

Majumdar, S. Mallick, B. N. (2003). Increased levels of tyrosine hydroxylase and glutamic acid decarboxylase in locus coeruleus neurons after rapid eye movement sleep deprivation in rats. Neurosci. Lett. 338, 193-6. 

Bourgin, P., Huitron-Resendiz, S., Spier, A. D. el al. (2000). Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J. Neurosci. 20, 7760-5. 

Darracq, L Gervasoni, D., Souliere, F. et al. (1996). Effect of strychnine on rat locus coeruleus neurones during sleep and wakefulness. Neuroreport 8,... 

Kodama, T. Koyama, Y. (2006). Nitric oxide from the laterodorsal tegmental neurons its possible retrograde modulation on norepinephrine release from the axon terminal of the locus coeruleus neurons. Neuroscience 138, 245-56. 

Aston-Jones G., Chiang C., Alexinsky T. (1991). Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog. Brain Res. 88, 501-20. 

Alreja M, Aghajanian G. Pacemaker activity of locus coeruleus neurons whole-cell recordings in brain slices show dependence on cAMP and protein kinase A. Brain Res 1991 556 339—343. Shiekhattar R, Aston-Jones G. Modulation of opiate responses in brain noradrenergic neurons by cAMP cascade changes with chronic morphine. Neuroscience 1993 57 879-885. 

Aghajanian, G. K. (1980) Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli. Brain Res., 186 492-498. 

Agonist/antagonist effects on serotonin receptors Time-dependent increases/decreases on dopamine and norepinephrine Age-dependent effects on MAO Increased firing of locus coeruleus neurons... 

Yang YR, Chang KC, Chen CL, Chiu TH. (2000) Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol 43 23-28. 

Several lines of evidence suggest that the locus coendeus is the site of the a2A-agonist-mediated sedative response. The a2A-subtype is abundantly expressed in locus coeruleus neurons (Wang et al. 1996). Administration of antisense oligonucleotides for the a2A-receptor subtype into the locus coeruleus of rats attenuated the hypnotic effect of dexmedetomidine reversibly (Mizobe et al. 1996). In the locus coeruleus of wild-type mice, 02-agonists suppressed the spontaneous firing rate of neurons but did not alter... 

Other hand, the locus coeruleus is known to be richly innervated with CRH im-munoreactive fibers (Valentino et al. 1993). Stress- or CRH-induced increases in locus coeruleus neuronal firing are blocked by CRH receptor antagonists and chronic antidepressant treatment (e.g., Valentino et al. 1990 Schulz et al. 1996), suggesting that anxiogenic effects of CRH are mediated through its actions on the locus coeruleus noradrenergic system (Butler et al. 1990). 

Subsequently, serotonin was shown to affect responses to excitatory amino acids in rat neocortical neurons, in cells of the ventrobasal thalamus, dorsal horn neurons, and rat locus coeruleus neurons (Aston-Jones et al. 1991 S. A. Eaton and Salt 1989 Murase et al. 1990 Read et al. 1990 J. N. Reynolds et al. 1988]. Whether the modulatory effect of serotonin is to enhance or attenuate the effect of the excitatory amino acid appears to depend on the brain region investigated. Also, many of the experiments used extracellular recording techniques, although Sizer et al. (1992] used intracellular current clamp in vitro experiments to investigate neurons of the rat entorhinal cortex and neocortex. In the entorhinal cortex and neocortex, the predominant effects of serotonin were to reduce and enhance, respectively, the response to excitatory amino acids. 

Aston-Jones G, Akoaka H, Charlety P, et al Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurones. J Neurosci 11 760-769, 1991... 

Arango V, Underwood MD, Mann JJ (1996) Fewer pigmented locus coeruleus neurons in suicide victims Preliminary results. Biol Psychiatry 39 112-120... 

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