Lisuride maleate

Lisuride maleate silica gel (CHCI3 MeOH) Amin, 1987... 

In some cases hydrochloride salts are not very water soluble due to the strength of association between the base and its counter ion, and other salts have to be used. For instance, salts may be prepared with di- or tricarboxylic acids, e.g. ergometrine tartrate, diethylcarbamazine citrate, sumatriptan succinate (Fig. 3.18) and lisuride maleate are all used because of the water insolubility of their hydrochlorides. Similarly strong monobasic organic acids such as mesilate are used to promote water solubility, as in the case of benzatropine mesilate (Fig. 3.18) andphentol-amine mesilate. In some instmces salts are too ready to absorb water from the atmosphere, for instance the muscle relaxant dmg atracurium is formulated as its besilate salt to avoid the problems of water absorption experienced with its mesilate. 

Fig 2 Reflectance scan of a chromatogram track with 90 ng of each substance per chromatogram zone 1 = lisuride dihydrogen maleate, 2 = methyseigide maleate, 3 = dihydroeigotamine mesylate, 4 = ergotamine tartrate. 

Lisuride dihydrogen maleate (h/Jj 30-35), methysergide maleate (h/ij 40-45), dihydroergotamine mesylate (hRf 45-50) and ergotamine tartrate (hRj 70-75) appeared as blue violet chromatogram zones on a yellow background. The detection limits — calculated for free base — were 3-4 ng substance per chromatogram zone. 

Herrman, W. M., Horowski, R., Dannehl, K., Kramer, U., and Lurati, K. (1977) Clinical effectiveness of lisuride hydrogen maleate A double-blind trial versus methysergide. Headache, 17 54-60. 

Itil, T. M., Herrmann, W. M and Akpinar, S. (1975) Prediction of psychtropic properties of lisuride hydrogen maleate by quantitative pharmaco-electroencephalogram. Int. J. Clin. Pharmacol., 12 221-223. 

Amin, M. (1987) Quantitative determination and stability of lisuride hydrogen maleate in pharmaceutical preparations using thin-layer chromatography. Analyst, 112, 1663-1665. 

Hiimpel, M., Nieuweboeg B., Hasan, S.H. and Wendt, H. (1981) Radioimmunoassay of plasma lisuride in man following intravenous and oral administration of lisuride hydrogen maleate effect on plasma prolactin level. Eur. J. Clin. Pharmacol., 20, 47-51. 

Structurally closely related to LSD, Lisuride (226) is a compound having a 3,3-dimethylureido substituent, at die 9-position of the ergoline skeleton, and was first prepared in 1960 as a dopamine Dj-receptor agonist (98). Lisuride, as its acid maleate, is commercially available under Ae names of Cuvalit, Dopergin, Eunal, or Lysenyl, and is used clinically as an antimigraine and also as a prolactin inhibitor. The pharmacological activi and toxicity of lisuride were... 

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