Liquid chromato-graphy-mass

Finally, in Part III, we will talk about putting the system to work on real-world applications. We will look at systematic methods development, both manual and automated, and the logic behind many of the separations that others have made. We will discuss how to interface the HPLC system to computers and robotic workstations. I will also give you my best guesses as to the direction in which HPLC columns, systems, detectors, and liquid chromato-graphy/mass spectrometer (LC/MS) systems will be going. 

R.M. Black and R.W. Read, Liquid chromato-graphy/mass spectrometry in analysis of chemicals related to the Chemical Weapons Convention, in Encyclopedia of Analytical Chemistry, R.A. Meyers (Ed.), John Wiley Sons, Chichester, 2000. 

Liu H, Sabus C, Carter GT, Du C, Avdeef A, Tischler M. In vitro permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromato-graphy/mass spectrometry detection. Pharm Res 2003 Nov 20(11) 1820-1826. 

Brown, F.R. and Draper, W.M., Matrix effect in particle beam liquid chromato-graphy/mass spectrometry and reliable quantification by isotope dilution, Biol. Mass Spectrom., 20, 515-521 (1991). 

Buchalla, R. Begley, T.H. Characterization of gamma-irradiated polyethylene terephthalate by liquid-chromato-graphy-mass-spectrometiy (LC-MS) with atmospheric pressure chemical ionization (APCI). Radiat. Phys. Chem. 2006, 75, 129-137. 

A.P. Bruins, T.R. Covey and J.D. Henion, Ion spray interface for combined liquid chromato graphy/atmospheric pressure ionization mass spectrometry, Anal. Chem., 59,2642 2646 (1987). 

MacCracken, R.J. and Kennedy, D.G. (1997). Determination of the furazolidone metabolite, 3-amino-2-oxazolidinone, in porcine tissues using liquid chromato-graphy-thermospray mass spectrometry and the occurrence of residues in pigs produced in Northern Ireland, J. Chromatogr. B, 691, 87-94. 

Hsieh, Y., Wang, G., Wang, Y., Chackalamannil, S., Brisson, J. M., Ng, K., and Korfmacher, W. A. (2002). Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromato-graphy/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16 944-950. 

Analysis of bioactive peptides by liquid chromato-graphy-high-resolution electrospray mass spectrometry, J. Chromatogr., A, 767, 77-85... 

Molina, C., Honing, M. and Barcelo, D. 1994. Determination of organophosphorus pesticides in water by solid-phase extraction followed by liquid chromato-graphy/high-flow pneumatically assisted electrospray mass spectrometry. Anal. Chem., 66 4444-4449. 

Figure 8.4. The SACI/MS3 spectra of the OTA daughter ion at m/z 358 (above) and of the ZAN daughter ion at m/z 303 (below). The OTA m/z 239+341 and ZAN m/z 163+189+207 signals are used for quantitative analysis. (Spectra acquired in positive-ion mode collision energy applied to the parent ion 80% of maximum value MS3 of daughter ions at 100% of maximum collision energy). (Reprinted from Rapid Communications in Mass Spectrometry 21,Flamini et al., A new sensitive and selective method for analysis of ochratoxin A in grape and wine by direct liquid chromato-graphy/surface activated chemical ionization-tandem mass spectrometry, p. 3740, Copyright 2007, with permission from John Wiley Sons, Ltd.)...

Crescenzi, C., Di Corcia, A., Moarcomini, A., Pojana, G., and Samperi, R., Method development for trace determination of poly(naphthalenesulfonate)-type pollutants in water by liquid chromato-graphy-electrospray mass spectrometry, J. Chromatogr. A, 923, 97-105, 2001. 

Wu CS, Sheng YX, Zhang YH, Zhang JL, Guo BL. Identification and characterization of active compounds and their metabolites by high-performance liquid chromato-graphy/Fourier transform ion cyclotron resonance mass spectrometry after oral... 

Ma, Y.C. and Kim, H.Y. (1995) Development of the online high-performance liquid chromato-graphy/thermospray mass spectrometry method for the analysis of phospholipid molecular species in rat brain. Anal. Biochem., 226(2), 293-301. 

These results, together with the assumption that C-5 was engaged in phosphomono-ester formation in ADP-X, indicated that compound X is a derivative of 3-deoxyribose with additional keto function(s) at C-2 or C-4 or both. Analyses with gas chromato-graphy/mass spectrometry (GC/MS) after acetylation and with high-performance liquid chromatography (HPLC) after dansylhydrazone formation also supported this view [12]. 

Chen, P., Chen, B., and Yao S., 2006. High-performance liquid chromato-graphy/electrospray ionization-mass spectrometry for simultaneous determination of taurine and 10 water-soluble vitamins in multivitamin tablets. Analytica Chimica Acta. 569 169-175. 

Gergov, M. Ojanpera, I. Vuori, E. Simultaneous screening for 238 drugs in blood by liquid chromato-graphy-ionspray tandem mass spectrometry with multiple-reaction monitoring, J.Chromatogr.B, 2003, 795, 41-53. 

Feng, F. Jiang, J. Dai, FT. Wu, J. Development and validation of a high-performance liquid chromato-graphy-electrospray ionization-mass spectrometry assay for the determination of zaleplon in human plasma, J.Chrornatogr.Sci., 2003, 41, 17-21. [LOD 100 pg/mL triazolam is internal standard]... 

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