Lipoxin A4 and

Machado F. S., Johndrow J. E., Esper L., Dias A., Bafica A., Serhan C. N., and Aliberti J. (2006). Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nature Med. 12 330-334. 

Coupling of 1-alkynes and vinyl halides14 (6, 61). This coupling reaction has been used extensively for synthesis of isomers of lipoxin A4 and B4, linear trihydroxy... 

Based on the strategies developed for HPETE and leukotriene-related metabolites, Wheelan et al. [35] studied the negative-ion ESI-MS and MS-MS spectra of dihydroxyeicosatrienoic acids (diHET), dihydroxyeicosatetraenoic acids (diHETE), and the triHETE lipoxins A4 and B4. Fragmentation in MS-MS allowed the determination of the hydroxy positions in the various molecules. 

Fierro IM, Colgan SP, Bernasconi G, Petasis NA, Clish CB, Arita M, Serhan CN (2003) Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol 170 2688-2694... 

Jozsef L, Zouki C, Petasis NA, Serhan CN, Eilep JG (2002) Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NE-kappa B and AP-1 activation, and 11, 8 gene expression in human leukocytes. Proc Natl Acad Sci USA 99 13266-13271... 

Lee TH, Horton CE, Kyan-Aung U, Haskard D, Crea AE, Spur BW (1989) Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. CUn Sci (Lond) 77 195-203... 

Maddox JE, Serhan CN (1996) Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion selective inactivation by dehydrogenation and reduction. J Exp Med 183 137-146... 

Papayianni A, Serhan CN, Brady HR (1996) Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J Immunol 156 2264—22672... 

Sodin-Semrl S, Spagnolo A, Mikus R, Barbaro B, Varga J, Fiore S (2004b) Opposing regulation of interleukin-8 and NF-kappaB responses by lipoxin A4 and serum amyloid A via the common hpoxin A receptor. Int J Immunopathol Pharmacol 17 145—156... 

Fierro IM, Kutok JL, Serhan CN Novel lipid mediator regulators of endothelial cell proliferation and migration Aspirin-triggered-15k-lipoxin A4 and lipoxin A4. J Pharmacol Exp Ther 2002 300 385-392. 

Qiu F-H, Devchand PR, Wada K, Serhan CN Aspirin-triggered lipoxin A4 and lipoxin A4 up-reg-ulate transcriptional corepressor NABl in human neutrophils. FASEB J 2001 15 2736-2738 (available at www.fasebj.oig). 

Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN Aspirin-triggered 15-epi-lipoxin A4 and LXA4 stable analogs are potent inhibitors of acute inflammation Evidence for antiinflammatory receptors. J Exp Med 1997 185 1693-1704. 

Takano T, Clish CB, Gronert K, Petasis N, Serhan CN Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. J Clin Invest 1998 101 819-826. 

Lefer AM, Stahl GL, Lefer DJ, Brezinski ME, Nicolaou KC, Veale CA, Abe Y, Smith JB Lipoxins A4 and B4 Comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. Proc Natl Acad Sci USA 1988 85 8340-8344. 

Lee TH, Crea AE, Gant y Spur BW, Matron BE, Nicolaou KC, Reardon E, Brezinski M, Serhan CN Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. Am Rev Respir Dis 1990 141 1453-1458. 

Romano M, Luciotti G, Gangemi S, Marinucci F, Prontera C, D Urbano E, Davi G Urinary excretion of lipoxin A4 and related compounds Development of new extraction techniques for lipoxins. Lab Invest 2002 82 1253-1254. 

Goh J., Baird A. W., O Keane C., Watson R. W. G., Cottell D., Bemasconi G., Petasis N. A., Godson C., Brady H. R., MacMathuna P. 2001. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 antagonize TNEa-stimulated neutrophU-enterocyte interactions in vitro and attenuate TNFa-indueed ehemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. Joum ofhmniuwhg. 167(5) 2772-2780. 

Ariel A., Chiang N., Arita M., Petasis N. A., Serhan C. N. 2003. Aspirin-triggered lipoxin A4 and B4 analogs bloek extracellular signal-regulated kinase-dependent TNF-a secretion from human T cells. Joum o bmnjmolo. 170(12) 6266-6272. 

Biteman B., Hassan I. R., Walker E., Leedom A. J., Dunn M., Seta F., Laniado-Schwartzman M., Gronert K. 2007. Interdependence of lipoxin A4 and heme-oxygen-ase in counter-regulating inflammation during corneal wound healing. 21(9) 2257-2266. 

Pouhot, M and Serhan, CN (1999) Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-alpha-initiated neutrophil responses and trafficking novel regulators of a cytokine-chemokme axis relevant to periodontal diseases. J Periodontal Res, 34, 370-373. 

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