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Dihydroxyeicosatrienoic acids

Based on the strategies developed for HPETE and leukotriene-related metabolites, Wheelan et al. [35] studied the negative-ion ESI-MS and MS-MS spectra of dihydroxyeicosatrienoic acids (diHET), dihydroxyeicosatetraenoic acids (diHETE), and the triHETE lipoxins A4 and B4. Fragmentation in MS-MS allowed the determination of the hydroxy positions in the various molecules. [Pg.571]

EpETrEsepoxyeicosatrienoic acids (Di)HETE=(di)hydroxyei-cosatetraenoic acids HpETEshydroperoxyeicosatetiaenoic acids DiHETrE dihydroxyeicosatrienoic acids LX=lipoxins PGUprostacyclins TX thromboxanes LT=leukotrienes PQsprostaglandins Hx=hepoxilins PGG, PGH=prostaglandin endoperoxides... [Pg.49]

Microsomal cytochrome P450 (CYP) monooxygenases are better known for their role in xenobiotic metabolism, a process which is crucial in the therapeutic and toxic effects associated with pharmaceuticals. However, they are also involved in the biosynthetic transformation of PUFA to epoxy-, mono-hydroxylated- and di-hydroxylated-metabolites. When AA is the substrate, CYP-reactions produce a range of epoxyeicosatrienoic acids (EET), hydroxyeicosatrienoic acids (HETE), and dihydroxyeicosatrienoic acids (DHET) (Eigure 3.5). [Pg.61]

Fig. 13.4 Fatty acid epoxides, such as 14,15-epoxyeico-satrienoic acid (14,15-EET), are metabolized by multiple pathways. EETs can undergo additional oxygenation by CYPs or cyclooxygenases (COXs), can be hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by epoxide... Fig. 13.4 Fatty acid epoxides, such as 14,15-epoxyeico-satrienoic acid (14,15-EET), are metabolized by multiple pathways. EETs can undergo additional oxygenation by CYPs or cyclooxygenases (COXs), can be hydrolyzed to dihydroxyeicosatrienoic acids (DHETs) by epoxide...
An important pathway for metabolism of EETs is hydrolysis to dihydroxyeicosatrienoic acids (DHETs) by epoxide hydrolases (EHs or EPHXs). There are at least five mammalian enzymes thought to contain EH activity EPHXl, EPHX2, EPHX3, EPHX4, and PEGl/MEST [140], Of these, soluble epoxide hydrolase (sEH/ EPHX2) is the most active for EET hydrolysis... [Pg.889]

Oliw EH, Lawson JA, Brash AR, Oates JA (1981) Arachidottic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids. J Biol Chem 256 9924-9931... [Pg.896]

Fang X, Hu S, Xu B, Snyder GD, Hannon S, Yao J, Liu Y, Sangras B, Falck JR, Weintraub NL, Spector AA(2006) 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. Am J Physiol Heart Circ Physiol 290 H55-H63... [Pg.900]

Cytochrome P450 catalyzes the monooxygenation of arachidonate to form a family of isomeric epoxyeicosatrienoic acids (EETs). These may be, in turn, transformed by the enzyme epoxide hydrolase to the corresponding diols, the dihydroxyeicosatrienoic acids (DHT). In addition, cytochrome P450 can also convert arachidonate into a family of nonchiral HETEs. [Pg.81]

See other pages where Dihydroxyeicosatrienoic acids is mentioned: [Pg.396]    [Pg.401]    [Pg.158]    [Pg.159]    [Pg.359]    [Pg.63]    [Pg.399]    [Pg.61]    [Pg.73]    [Pg.154]    [Pg.119]    [Pg.396]    [Pg.401]    [Pg.158]    [Pg.159]    [Pg.359]    [Pg.63]    [Pg.399]    [Pg.61]    [Pg.73]    [Pg.154]    [Pg.119]    [Pg.440]   
See also in sourсe #XX -- [ Pg.81 ]



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