Lipid spray drying

Caprylic/capric triglyceride, cosmetically useful lipid, 7 833t Capsanthin, 24 560 Capsicum group, 23 164-165 Capsorubin, 24 560 Capsular polysaccharides, 20 455 Capsules. See also Microencapsulation extruding, 16 446 pharmaceutical, 18 708 produced by spray drying, 16 447-448 Capsule standard platinum resistance thermometers, 24 445 Captafol, 23 629, 647 Captan, 23 628 Captiva camera, 19 307 Captive hydrogen, 13 841 Captopril, 5 148... 

Bot, A.I., D.J. Smith, S. Bot, L. Dellamary, T.E. Tarara, S. Harders, W. Phillips, J.G Weers, and C.M. Woods, Receptor-mediated targeting of spray-dried lipid particles coformulated with immunoglobulin and loaded with a prototype vaccine. Pharm Res, 2001.18(7) 971-9. 

The use of freeze-drying avoids an inherent disadvantage of spray drying, i.e., the elevated processing temperature, which accelerates the oxidation of polyunsaturated lipids. 

Other methods to prepare solid micelle dispersion, such as spray drying of a drug containing micelle solution onto solid core materials or solvent emulsiLcation technique to prepare solid lipid nanoparticles, can be found in literature (Karmazina, 1997 Burruano et al., 1999 Luo et al., 2006 Radomska-Soukharev et al., 2006). 

AIR particles are low-density lipid-based particles that are produced by spray drying lipid-albumin-drug solutions. These particles are characterized by their porous surface characteristics and large geometric diameter while having a low aerodynamic diameter [176,177], This technology has been used to produce porous particle powder formulations of L-dopa that have been investigated for the treatment of Parkinson s disease [178],... 

Whey protein concentrate. The whey protein used was prepared by ultrafiltration and spray drying. Protein content (N x 6.55) was 68% (dry weight). Lipid content was 7.1% (dry weight). In order to study heat induced aggregation by spectrophotometric methods the turbidity of the dilute protein dispersions was too high. The turbidity of whey protein dispersions is caused by lipids associated with proteins probably in the form of emulsified oil droplets. This fraction was removed by precipitation at pH 4.5 from dispersions made in dist. water and separated by centrifugation at 40 000 xg. 

Figure 2. A diagrammatic presentation of a fermentation system for the production of a singie cell oil. The main fermenter is inoculated from a smaller vessel at about 10% (v/v). Additional nutrients, including glucose, may be added to the microbial culture within the fermenter during growth. The process operates in a batch mode so that when the cells reach their highest lipid contents (see Figure 3), the fermenter is emptied, the cells are removed from the broth, and then finally they are spray-dried. In this form, the oil within the cells is stable and can be extracted by solvents whenever, and wherever, is convenient. (From 50, with kind permission of the author. Dr. David J. Kyle, and the publishers.)...

Solid lipid nanoparticles can be converted to solid dosage forms by, for example, granulation, whereby the SLN dispersion is used as the granulating fluid, or as the wetting agent in the extrusion process, or by spray-drying or lyophilizing the SLN dispersion. 

Freitas, C. Muller, R.H. Spray-drying of solid lipid nano- 72. particles (SLN). Eur. J. Pharm. Biopharm. 1998,4(5,145-151. 

Eldem, T. Speiser, P. Hincal, A. Optimization of spray-dried and -congealed lipid micropellets and characterization of the surface morphology by scanning electron microscopy. Pharm. Res. 1991, 8, 47-54. 

Chauhan B, Shimpt S, Paradkar A. Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS niarm Sci Tech 2005 6 E405-B412. 

Transfer the solution to a pear-shaped or a round-bottom flask and, employing a rotary evaporator, remove the solvents at temperatures above T under negative pressure, leaving a thin layer of dried lipid components in the flask (see Note 2). Other methods of drying the lipid ingredients include lyo-philization and spray drying (23). 

The myofibrillar proteins of fish are those proteins soluble in 0.6M NaCl (14). These proteins have been modified with Rhozyme P-11 at an enzyme-to-protein ratio of 1 75 at 30 °C, pH 6.6 for 1 hr. The modified myofibrillar protein was quantitatively recovered as a hexametaphosphate complex at pH 3. Residual lipids were removed by solvent extraction of the complex. After a solution of the phosphate-protein complex was neutralized to pH 7, it was spray-dried or freeze-dried to yield a freely soluble product which was 93.5% protein, 0.15% lipid, and 1.4% phosphate. 

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