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Linkage marker

Summar ML. Molecular genetic research into carbamoyl-phosphate synthase I molecular defects and linkage markers. J Inher Metab Dis (Suppl 1) 1998 21 30-9. [Pg.1534]

Amelung PJ, Panhuysen CI, Postma DS, et al Atopy and bronchial hyperresponsiveness Exclusion of linkage markers on chromosomes llq and 6p. Clin Exp Allergy 1992 22 1077—1084. (Ill)... [Pg.30]

Goldman D (1988). Molecular markers for linkage of genetic loci contributing to alcoholism. In M. Galenter (ed.), Recent Developments in Alcoholism (Vol. 6, pp. 333-349). Plenum Press, New York. [Pg.266]

Fig. 3.2 G raph demonstrating the effect of varying linkage disequilibrium (D ) on relative risk. The underlying susceptibility SNP (D = 1.0) yields a relative risk of 2.5 and the marker and susceptibility SNPs have equal frequencies. Fig. 3.2 G raph demonstrating the effect of varying linkage disequilibrium (D ) on relative risk. The underlying susceptibility SNP (D = 1.0) yields a relative risk of 2.5 and the marker and susceptibility SNPs have equal frequencies.
Marsh D, Neely J, Breazeale D et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total semm immunoglobin E concentrations. Science 1994 264 1152-1156. [Pg.229]

Kruglyak L. The use of a genetic map of biallelic markers in linkage studies. Nature Genet 1997 17 21-24. [Pg.231]

The second type of investigation is the linkage study or genome scan in which there is no predetermined biological hypothesis for the genetic basis of the phenotype. This type of study measures the degree to which the trait is linked to markers which are placed randomly across the whole genome. These studies are discussed further in Section 22.3. [Pg.445]

Linkage The closer two or more markers (e.g., polymorphisms) on a chromosome are together the lower is the probability that they will be separated during DNA repair or replication. Therefore, the closer they are linked together, the greater is the probability that they will be inherited together. [Pg.535]


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