Lincomycin hydrochloride

Pharmacology and Uses. Lincomycin hydrochloride (Lincocin) is available in oral dosage forms and as a sterile solution for injection. After... 

The following procedure is described in U.S. Patent 3,475,407. A solution of 50 g of lincomycin hydrochloride, 120 g of triphenylphosphine, and 500 ml of acetonitrile in a 3 liter flask equipped with a stirrer was cooled in an ice bath and 500 ml of carbon tetrachloride was added in one portion. The reaction mixture was then stirred for 18 hours without addition of ice to the cooling bath. The reaction was evaporated to dryness under vacuum on a 50° to 60°C water bath, yielding a clear, pale yellow viscous oil. An equal volume of water was added and the mixture shaken until all of the oil was dissolved. The resulting suspension of white solid (03PO) was filtered through a sintered glass mat and discarded. The filtrate was adjusted to pH 11 by addition of 6N aqueous sodium hydroxide. A solid precipitated. 

Lincomycin Hydrochloride Glass column (1.5 M x 3 mm) packed with acid-washed silanised diatomaceous support impregnated with 3% w/w of phenyl methyl silicone fluid (50% of phenyl) (OV-17 is also suitable) and maintained at 260 °C Inlet-port and detector maintained at 260-290 °C Carrier gas Helium-with a flow rate of about 45 ml minute-1. Solutions (1), (2) and (3) Calculate the content of c18h34n2o6s, HC1, H20 in lincomycin hydrochloride BPCRS... 

Lincos amides clindamycin hydochloride clindamycin palmitate hydrochloride clindamycin phosphate lincomycin hydrochloride monohydrate... 

The use of triphenylphosphine-carbon tetrachloride to convert lincomycin (1) into clindamycin (2) has already been mentioned (see Section I, p. 226) the 7-bromo and 7-iodo analogs of 2 were also prepared by treatment of lincomycin hydrochloride with triphenylphosphine and carbon tetrabromide or carbon tetraiodide, with acetonitrile as the solvent.3... 

It is routine to standardize Karl Fischer reagents, or even a coulometer, with a standard such as lincomycin hydrochloride monohydrate, which contains 3.91 wt% H20. The coulometer is run until the end point is reached, indicating that the Karl Fischer reagent is dry. A port is opened briefly to add solid lincomycin, which is then titrated to the same end point. Then an unknown is added and titrated in the same manner. Find the wt% HzO in the unknown. 

Anomeric center reactivity has been observed for the API lincomycin hydrochloride. Lincomycin HC1 contains a carbohydrate portion that undergoes thioglycoside hydrolysis at the carbohydrate anomeric center (Fig. 127) (177). 

The following procedure is described in US Patent 3,475,407. A solution of 50 g of lincomycin hydrochloride, 120 g of triphenylphosphine, and 500 ml of acetonitrile in a 3 liter flask equipped with a stirrer was cooled in an ice bath and 500 ml of carbon tetrachloride was added in one portion. The reaction mixture was then stirred for 18 hours without addition of ice to the cooling... 

Lincomycin Hydrochloride Lincomycin hydrochloride is incompatible with... 

Infra-red Spectrum. Principal peaks at wavenumbers 1655,1104, 1075, 1564, 1040, 1262 (lincomycin hydrochloride, KBr disk). 

Acepromazine Maleate 461.0 Lincomycin Hydrochloride 484.5 Hydrocortisone Sodium... 

Lincomycin Hydrochloride EP Sodium Valproate Enteric-coated Tablets BP... 

Formation of soluble hydrochlorides of basic drugs does not necessarily result in improved bioavailability as was illustrated by comparative absorption studies of tetracyclines and lincomycin and their salts. " " Tetracycline-free bases gave higher plasma levels than their hydrochloride salts, while lincomycin hydrochloride had a lower bioavailability than the hexadecylsulfa-mate salts. These differences have been attributed to a common ion effect with gastric HCl following oral administration. 

Uncomycin Hydrochloride, USP. Lincomycin hydrochloride (Lincocin). which differs chemically fnmi other... 

Lincomycin hydrochloride (anhydrous) 8S9 - 18 - 7 Lincomycin hydrochloride (monohydrate) 7179- 49 9... 

Lincomycin hydrochloride monohydrate is a white or almost white, crystalline powder. It is odorless or has a faint mercaptan - like odor and has a bitter taste. 

Lincomycin hydrochloride has two polymorphic forms (A and B). This was detected by their x - ray diffraction which showed the following interplanar spacing for the two crystalline forms (7). 

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