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Lignans properties

AYRES D c, LOIRE j D (1990) Lignans chemical, biological and clinical properties, Cambridge, Cambridge University Press. [Pg.295]

Another anti-cancer agent in clinical use is podophyllotoxin (3-59) this has an aryl tetrahydronaphthalene lignan lactone skeleton, and demonstrates potent tubulin-binding, anti-mitotic properties (Scheme 3.16) [30]. The Sherburn group [31] prepared this molecule by a tris(trimethylsilyl)silane promoted conversion of thionocarbonate 3-55 into the lactone 3-58, which proceeded with a yield of 38 %. As intermediates, the radicals 3-56 and 3-57 can be assumed. [Pg.230]

Martinez Nieto, L., D. Morales Villena, and J. M. Jimenez Castillo. Mannitol extraction from olive tree pruning residues. Study of some physicochemical properties of the aqueous extract. Afinidad 1978 35 487-489. Viviers, P. M., D. Ferreira, and D. G. Roux. (+)-Africanal, a new lignan of aryltetrahydronaphthalene class. Tetrahedron Lett 1979 1979 3773—3776. Tomas, F., and F. Ferrers. Flavonoids of Olea europaea. An Quim Ser C 1980 76 292-293. [Pg.392]

Most of these compounds, e.g. quercetin, possess various degrees of antioxidant or free radical scavenging properties. A number of phenolic compounds have medicinal properties and have long been used as drugs. For example, etoposide and teniposide, two lignans, are anticancer drugs. [Pg.360]

The traditional Chinese herbal medicine Shin-i is highly praised for its antiinflammatory effect [80]. Magnoshinin 164 (Scheme 12.24), isolated from the dry flower buds of Magnolia ulicifolia, has been shown to be the lignan responsible for this interesting biological property [81]. [Pg.371]

Among the major groups of flavonoids in the human diet are the flavonols, proanthocyanidins (which include the catechins), isoflavonoids, flavones, and flavanones. The closely related lignans (resorcyclic acid lactones) have similar properties as flavonoids, and are therefore included here for completeness. Quercetin, a flavonol, is the most predominant flavonoid in the human diet and estimates of human consumption are in the range of 4 to 68 mg/day. Among these studies, the Japanese population had the highest levels of flavonol intake, which was mainly attributed to their green tea consumption. [Pg.338]

Lignans are colorless, crystalline, solid substances widespread in the plant kingdom (mostly as metabolic intermediaries) and having antioxidant, insecticidal, and medicinal properties. Plants containing lignans with anticancer properties include the following ... [Pg.573]

Lignans are a well-known class of widespread natural phenolic compounds that exhibit great structural and biological diversity and are commonly found in vascular plants from various families [1]. They are present at different levels of abundance in all plant parts, including roots, rhizomes, hardwood, bark, stems, leaves, flowers, fruits and seeds [2]. Lignans are of considerable pharmacological and clinical interest and are used in the treatment of cancer and other diseases [3]. The extensive pharmaceutical use of lignans is due to their antitumor, antiviral and hepatoprotective properties as well as many other beneficial activities. [Pg.104]

Ayres, D.C. Loike, J.D. In Lignans. Chemical, Biological and Clinical Properties Chemistry and Pharmacology of Natural Products, Phillipson, J.D., Ayres, D.C., Baxter, H., Eds. Cambridge University Press Cambridge (UK), 1990. [Pg.413]


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See also in sourсe #XX -- [ Pg.201 ]




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