Light-sensitive drug

The apparatus used for the in vitro dissolution studies consisted of a two-piece 1 L reaction kettle (Fisher Scientific Co. Cat. No. 11-847B). The top cover has four openings, three of which were stoppered and the center one left open for the stirrer shaft. The exterior of both the top and bottom pieces were painted black to allow use with light-sensitive drugs. Stirring was provided by a three-blade, polyethylene stirrer... 

Photolysis is another common degradation pathway because light-sensitive drugs can be affected by either sunlight or artificial light sources such as... 

Eisenbrand J. Protection of light-sensitive drugs by colored glass. Pharm Ztg 1927 72 247-248. 

Eisenbrand J. Protection of the light sensitive drugs, 11. Pharm Ztg 1927 72 1275-1276. Eisenbrand J Protection of light-sensitive drugs by means of colored glassware. III. Pharm Ztg 1929 74 263. 

Tonnesen HH, Karlsen J. Studies on curcumin and curcuminoids. X. The use of curcumin as a formulation aid to protect light sensitive drugs in soft gelatin capsules. Int J Pharm 1987 38 247. 

Eisenbrand VJ. Protection of light-sensitive drugs. Pharm Ztg 1927 72(81) 1275-1276. (Scientific Communication, A method for the Testing of the Light Sensitivity of Drug Substances). CA 21,1689. 

Recommendations for Official Regulations for Light-Sensitive Drugs...184... 

RECOMMENDATIONS FOR OFFICIAL REGULATIONS FOR LIGHT-SENSITIVE DRUGS... 

A number of case histories are presented in this chapter that illustrate the formulation problems raised by light-sensitive drug substances. These range from the study and formulation of parenteral presentations, in which the product is in solution or suspension form and the instability most closely mirrors that of the drug substance pharmaceutical ointments, in which the drug substance is incorporated as a suspended material in a semisolid base to the physical effects on a tablet formulation where the active is present as solid component. 

The second case study represents an interesting situation combining the problems of a light-sensitive drug substance incorporated into a presentation that will be exposed to sunlight during patient use. It also represents a situation partway between the solid stability of the drug substance and its photostability in the solution phase. 

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