LHRH polypeptide

United States Patent 4,767,628 assigned to Imperial Chemical Industries describes a similar lactide/glycolide delivery system for LHRH polypeptide (122,123). A multiphase release pattern is again postulated. The first phase occurs by diffusion of drug through aqueous polypeptide domains linked to the exterior surface of the matrix. 

Calcitonin, LHRH, lypressin, and somatostatin have been formulated in lactide/glycolide copolymers as injectable, controlled release formulations (117). Various agonistic and antagonistic analogs have been studied. Generally these compounds are hydrophilic polypeptides,... 

W. E., Long-acting delivery systems for polypeptides. Inhibition of rat prostate tumors by controlled release of [D-Trp ]-LHRH from injectable microcapsules, Proc. Natl. Acad. Sci. 

LG j8-Lact< obulin LGL Large granular lymphocyte LH Luteinizing hormone LHRH Luteinizing hormonereleasing hormone LI Labelling index LIS Lateral intercellular spaces LMP Low molecular mass polypeptide... 

Ascorbic acid stimulates the release of acetylcholine and noradrenaline from isolated synaptic vesicles (Kuo et aL, 1979). The release mechanisms of acetylcholine are more sensitive to ascorbic acid than those of noradrenaline (2-2.5 jlM vs. 20 xM of EC50 for ascorbic acid). Ascorbic acid also enhances the release of vasoactive intestinal polypeptide from neuroblastoma (Brick et aL, 1985) and that of luteinizing hormone-releasing hormone (LHRH) from the mediobasal hypothalamus in vitro (Miller and Cicero, 1986). The latter effect may not be due to the reductive property of ascorbic acid, since another reducing agent, sodium metabisulfite, did not induce the release of LHRH. 

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