LH-Indazoles

CN (llp)-l l,17-dihydroxy-21-[[[[l-(phenylmethyl)-lH-indazol-3-yl]oxy]acetyl]oxy]pregn-4-ene-3,20-dione... 

Free Electron Molecular Orbital method colour and constitution, 1, 342 Freelingyne occurrence, 4, 706 Free radical processes in photography, 1, 387-389 Friedlander synthesis quinolines, 2, 443 thioindigo dyes, 4, 910 Fries rearrangement chroman-4-one synthesis from, 3, 850 Fructose, 1-deoxy-13C NMR, 4, 575 Frusemide as diuretic, 1, 174 metabolism, 1, 245 FS-32 — see lH-Indazole, l-[3-... 

Bendazac chloride ([(l-benzyl-lH-indazol-3-yl)oxy]acetic acid chloride) Manufacturing Process... 

To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of l-benzyl-3-(3-(dimethylamino) propoxy)-lH-indazole 70%, M.P. 154-156°C. 

Chemical Name lH-Indazole-3-carboxamide, l-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, monohydrochloride, 3-endo-... 

Preparation of methyl- and ethyl 2-(5,7-dimethyl-lH-indazol-3-yl)-5-pyridin-3-yl-thiazole-4-carboxylate... 

Selected 5,7-dimethyl-lH-indazole derivatives are provided in Table 1. 

Methyl-lH-indazol-3-yl)-5-pyridin- 3- yl-thiazole-4-carboxylic acid methyl- (1 -methyl-piperidin-4-yl)-amide 1 H 0 1... 

Difluoro-phenyl)-2-(7-methyl-lH-indazol-3-yl)-thiazol-4-yl] -(4-methyl-piperazin-1 -yl) -methanone 1 H A-n. VS F w. NY... 

Selected experimental 5,7-dimethyl-lH-indazole agents provided in Table 1 had MIC values of 10 xM or less in the methicillin-resistant Staphylococcus aureus assay. 

Oinuma (5) prepared lH-indazole derivatives, (IV), which were effective as JNK inhibitory agents and as a medicament for the treatment of inflammatory disorders. 

D-Glucopyranoside derivatives containing l,3-dihydro-benzoimidazol-2-one, (V), and lH-indazole, (VI), prepared by Urbanski (4) and Patel (5), respectively, were effective in treating insulin resistance syndrome and reducing related risk factors for the development of Type II diabetes. 

Preparation of l-(2-azido-propyl)-6-methoxy-3-methyl-lH-indazole... 

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