Piperidine, Methyl-

Piperidine, 1-methyl- CNMR, 2, 15<76JA3778) dipole moment, 2, 160 <67JCS(B)493, 70JCS[Pg.42]

N,0-Dimethyl hydroxyl amine hydrochloride Methylamine, N-methoxy-, hydrochloride (8) Methanamine, N-methoxy-, hydrochloride (9) (6638-79-5) N-Methylpiperidine Piperidine, 1-methyl- (8,9) (626-67-5) N-tert-Butoxycarbonyl-L-leucine hydrate Leucine, N-carboxy-, N-tert-butyl ester, L- (8) L-Leucine, N-[(l,l-dimethylethoxy)carbonyl]- (9) (13139-15-6)... 

Diethoxymethylsilylpropoxy)-2,2,6,6-tetramethyl] piperidine Methyl salicylate p-Nonyl phenol 1,2,2,6,6-Pentamethyl-4-piperidinol Phenyl phosphonic acid... 

Methyl (4-methyl-2-nitrobenzenesulfonyl) acetate refluxed 20 hrs. in 95%-metha-nol containing piperidine methyl 4-methyl-2-nitrophenyl sulfone. Y 95%. F. e. and limitations s. R. T. Coutts and E. M. Smith, Can. J. Chem. 45, 975 (1967). 

Like butadiene, allene undergoes dimerization and addition of nucleophiles to give 1-substituted 3-methyl-2-methylene-3-butenyl compounds. Dimerization-hydration of allene is catalyzed by Pd(0) in the presence of CO2 to give 3-methyl-2-methylene-3-buten-l-ol (1). An addition reaction with. MleOH proceeds without CO2 to give 2-methyl-4-methoxy-3-inethylene-1-butene (2)[1]. Similarly, piperidine reacts with allene to give the dimeric amine 3, and the reaction of malonate affords 4 in good yields. Pd(0) coordinated by maleic anhydride (MA) IS used as a catalyst[2]. 

The replacement of the /V-methyl group on the nitrogen atom of the piperidine ring of morphine and analogues by aHyl, isopropyl, or methyl cyclopropyl, an isopropyl isostere, results in compounds which antagonize opioid responses, especially respiratory depression. Naloxone [465-65-6] C22H2 N04 (10... 

Halo-substituted 3-hydroxypyridazin-6(lFf)-ones react in some instances by cine substitution. For example, 4-chloro-l-methyl-2-phenylpyridazin-6(lFf)-one, when treated with piperidine, yields a mixture of the corresponding 4- and 5-piperidino isomers in nearly equal amounts. 

With secondary amines such as piperidine or dimethylamine the formal products (169) of cine substitution are obtained with primary amines e.g. /-butylamine), in addition to the displacement product (173), a rearranged product (174) is obtained in which the nitrogen-bearing methyl becomes exocyclic 80CC123). Earlier studies on the reaction of... 

Piperidine, l-(2-hydroxythiobenzoyI)-neutron diffraction, 2, 116 Piperidine, 4-hydroxy-2,2,6-trimethyI-as local anaesthetic, 1, 179 Piperidine, JV-methoxycarbonyl-electrolytic oxidation, 2, 374 Piperidine, 2-methyl-synthesis, 2, 524 Piperidine, 3-methyI-mass spectrometry, 2, 130 Piperidine, C-methyl-NMR, 2, 160 Piperidine, JV-methyl- C chemical shifts, 2, 15 catalyst... 

If, however, the /7-nitrophenyl ester of iV-henzoyl-L-leucine is treated with 1-methyl-piperidine in chloroform for 30 min and then coupled with glycine ethyl ester, the dipeptide isolated is almost completely racemic. Furthermore, treatment of the p-nitrophenyl ester of iV-benzoyl-L-leucine with 1-methylpiperidine alone leads to the formation of a crystalline material, C13H15NO2, having strong IR bands at 1832 and 1664 cm . Explain these observations, and suggest a reasonable stmcture for the crystalline product. 

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