Bendazac chloride

Bendazac Chloride (1 -benzyl-1 H-indazol-3-yl)oxy] acetic acid chloride Manufacturing Process... 

Hydrocortisone (25 g) and Bendazac chloride (21 g) are suspended in anhydrous dioxane (250 ml). Pyridine (6 ml) is added and the solution is kept under stirring for 2 hours at room temperature, Pyridine hydrochloride which separates is filtered and the clear dioxane solution is added, under strong stirring, to a solution of sodium bicarbonate (20 g) in distilled water (2,500 ml). The colorless precipitate which is formed is filtered, washed with water and dried on a porous plate. The substance crystallizes from ethanol. Needles. MP 174°-176 t Yield 75%. 

Bendazac chloride ([(l-benzyl-lH-indazol-3-yl)oxy]acetic acid chloride) Manufacturing Process... 

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