Mutagenicity lewisite

Stewart, D.L., E.J. Sass, L.K. Fritz and L.B. Sasser. 1989. Toxicology Studies on Lewisite and Sulfur Mustard Agents Mutagenicity of Sulfur Mustard in the Salmonella Histidine Reversion Assay. Final Report from Pacific Northwest Laboratories (PNL-6873) to U.S. Army Medical Research and Development Command, Fort Detrick, MD, AD A213102. 

There are no data on human exposure from which to predict the long-term effects from Lewisite. There is no substantial evidence to suggest that Lewisite is carcinogenic, teratogenic, or mutagenic (Goldman and Dacre, 1989). The committee appointed by the National Academy of Science reported a causal relationship between Lewisite exposure and chronic respiratory diseases, and also that acute, severe injuries to the eye from Lewisite will persist (Pechura and RaU, 1993). 

Jostes RF, Rausch RJ and Sasser LB (1989a). Toxicology studies on lewisite and sulphur mustard agents mutagenicity study of sulphur mustard (HD) in Chinese hamster ovary cells. Report AD-A216449. Fort Detrick Frederick, MD, USA US Army Research and Development Command. 

Stewart DL, Sass EJ, Fritz LK, Sasser LB (1989a) Toxicology studies on lewisite and sulfur mustard agents mutagenicity of sulfur mustard in the Salmonella histidine reversion assay. PNL-6873 (DTIC AD A213102). Pacific Northwest Laboratories. Prepared for the U.S. Department of the Army, Medical Research and Development Command, Fort Detrick, MD. 

A no-observed adverse-effect level of 0.016 mg/kg/ day in rabbits and 1.5mg/kg/day in rats was identified (Daniels et al., 1990). Lewisite is capable of producing DNA damage however, direct tests of its mutagenic potential have been inconclusive (Datta et al., 2007). 

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