Lewis, Mitchell

The lac repressor monomer, a chain of 360 amino acids, associates into a functionally active homotetramer. It is the classic member of a large family of bacterial repressors with homologous amino acid sequences. PurR, which functions as the master regulator of purine biosynthesis, is another member of this family. In contrast to the lac repressor, the functional state of PurR is a dimer. The crystal structures of these two members of the Lac I family, in their complexes with DNA fragments, are known. The structure of the tetrameric lac repressor-DNA complex was determined by the group of Mitchell Lewis, University of Pennsylvania, Philadelphia, and the dimeric PurR-DNA complex by the group of Richard Brennan, Oregon Health Sciences University, Portland. 

Kee RJ, Rupley FM, Meeks LM, Miller JA. A fortran chemical kinetics package for the analysis of gas-phase chemical kinetics. Livermore (CA) Sandia National Laboratories 1996 [SAND96-8216]. Kee RJ, Rupley FM, Miller JA, Coltrin ME, Grcar JF, Meeks E, Moffat HK, Lutz AE, Dixon-Lewis G, Smooke MD, Warnatz J, Evans GH, Larson RS, Mitchell RE, Petzold LR, Reynolds WC, Caracotsios M, Stewart WE, Glarborg P. CHEMKIN Collection, Release 3.5. San Diego (CA) Reaction Design, Inc. 1999. 

Di(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in rodents is not due to the parent diester per se, but rather to its metabolites. With mono(2-ethyl-hexyl) phthalate, the two proximate peroxisome proliferators were found to be the (co-l)-hydroxy (IX) and keto (VI) metabolites, while for 2-ethylhexanol the proximate peroxisome proliferator was 2-ethylhexanoic acid (Mitchell et al., 1985 Elcombe Mitchell, 1986 Cornu etal, 1992 Lewis Lake, 1993). 

Melnick M, Reich SH, Lewis KK, Mitchell L, Ngyen D, Trippe AJ, Dawson H, Davies JF, Appelt K, Wu B-W, Musick L, Gehlhaar DK, Webber S, Shetty B, Kosa M, Kahil D, Andrada D. Bis-tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design. J. Med. Chem. 1996 39 2795-2811. 

Hickey DMB, Leeson PD, Novelli R, Shah VP, Burpitt BE, Crawford LP, Davies BJ, Mitchell MB, Pancholi KD, Tuddenham D, Lewis NJ, O Farrel C (1988) J Chem Soc Perkin Trans 1 3103... 

K Mitchell, RG Brown, DW Yuan, SC Chang, RE Utecht, DE Lewis. J Photochem Photobiol A Chem 115 157, 1998. 

Snell, T., Mitchell, J.L. and Burbank, S.E. (1996) Rapid toxicity assessment with microalgae using in vivo esterase inhibition, in G.K. Ostrander (Ed.), CRC Press/Lewis Publishers, Boca Raton, Florida, U.S.A., pp. 13-22. 

Jenny P. Glusker Mitchell Lewis Miriam Rossi... 

Reprinted, with permission, from the cover of Science., March 1, 1996 [vol 271 ] and from Dr. Mitchell Lewis, University of Pennsylvania School of Medicine.)... 

Raftos J, Bauer GE, Lewis RG, Stokes GS, Mitchell AS, Young AA,MaclachlanI. Clonidine in the treatment of severe hypertension. MedJ Aust (1973) 1, 786-93. 

The phenothiazine drugs listed in Table 7 are all capable of cross-reacting with the phenothiazine antihistamines, and all of these compounds are potential photosensitizers (Lewis and Sawicky 1955). Often a photoallergic reaction occurs in combination with the allergic eczematous contact dermatitis. The systemic administration of the phenothiazine drugs shown in Table 7 may produce an eczematous contact dermatitis medicamentosa in individuals sensitized by such topical exposure. Cross-reactions readily take place between these phenothiazines and the related antihistamines (Mitchell and Ongley 1972). 

Lewis, D. (2009). Ramseyan humility. In D. Braddon-Mitchell and R. Nola, eds.. Conceptual Analysis and Philosophical Naturalism. MIT Press, pp. 203-22. Loar, B. (1997). Phenomenal states second version. In N. Block, O. J. Flanagan, and G. Giixeldere, eds.. The Nature of Consciousness. MIT Press. 

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