Brennan, Richard

The lac repressor monomer, a chain of 360 amino acids, associates into a functionally active homotetramer. It is the classic member of a large family of bacterial repressors with homologous amino acid sequences. PurR, which functions as the master regulator of purine biosynthesis, is another member of this family. In contrast to the lac repressor, the functional state of PurR is a dimer. The crystal structures of these two members of the Lac I family, in their complexes with DNA fragments, are known. The structure of the tetrameric lac repressor-DNA complex was determined by the group of Mitchell Lewis, University of Pennsylvania, Philadelphia, and the dimeric PurR-DNA complex by the group of Richard Brennan, Oregon Health Sciences University, Portland. 

Kurokawa R, Kalafus D, OgUastro MH, Kioussi C, Xu L, Torchia J, Rosenfeld MG, Glass CK (1998) Differential use of CREB binding protein-coactivator complexes. Science 279 700-703 Kwok RP, Lundblad JR, Chrivia,JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370 223-226... 

Richards, J., Guzman, R., Yang, J., Nandi, S., and Konrad, M. (1980). Chemical carcinogenesis of mammary epithelium in cell culture, page 467 in Cell Biology of Breast Cancer, McGrath, C.M., Brennan, M.J., and Rich, M.A., Eds. (Academic Press, New York). 

Richard J. Brennan, Tatiana Nikolskya and Svetlana Bureeva... 

Novartis Pharma AG, Basel, Switzerland Richard J. Brennan GeneGo Inc., Encinitas, CA, USA Nathan Brown The Institute of Cancer Research, Royal Cancer Hospital, Belmont, Sutton, Surrey, UK Svetlana Bureeva GeneGo Inc., Encinitas, CA, USA Dirksen E. Bussiere Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Emeryville, CA, USA Ye Che Exploratory Medicinal Sciences, Pfizer Global Research Development, Groton, CT, USA... 

Richard 0 Kennedy, W. J. J. Finlay, Stephen Hearty, Paul Leonard, Joanne Brennan, Sharon Stapleton, Susan Townsend,... 

Brandon D. Jeffy Joseph Milano and Richard J. Brennan ... 

Richard J. Brennan, Preclinical Safety, Sanofi SA, Waltham, MA, USA... 

Holcroft, B., Roberts, G. G., Barraud, A., and Richard, J., Electron. Lett., 23, 446, 1987. Brennan, J. D., Kallury, M. R., and Kmll, U. J., Transduction of the reaction between urea and covalently immobilized urease by fluorescent amphiphilic membranes, Thin Solid Films, 244, 898, 1994. 

F. Rezaei, T.L. Richard, R.A. Brennan and B.E. Logan, Substrate-enhanced microbial fuel cells for improved remote power generation from sediment-based systems, Environ. Sci. Technol. 41,2007,4053-4058. 

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