Leukocytes accumulation

Hallenbeck, J.M., Dutka, A.J., Tanishima, T., Kochanek, P.M., Kumaroo, K.K., Thompson, C.B., Obrenovitch, T.P. and Contreras, T.J. (1986). Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early post ischemic period. Stroke 17, 246-253. 

From the marine alga Stypopodium flabelliforme, several diterpenoids with interesting biological properties were isolated. The diterpenoid epitaondiol exhibited a potent anti-inflammatory activity related to inhibition of human PLA2 activity and leukocyte accumulation [64], Additionally, epitaondiol has been shown as a potent calcium antagonist in... 

In the ovary the ovulatory surge of LH increases blood flow [98]. This is accompanied by an increase in vascular permeability in the follicles resulting in oedema which persists through the time of follicle rupture and ovulation. The effect of LH can be mimicked by histamine but not by FSH or serotonin. Leukocytes accumulate in Graafian follicles near the time of ovulation and fibroblasts migrate from the theca layer to the stratum granulosum. 

Squadrito F, et al. Cyclosporin-A reduces leukocyte accumulation and protects against myocardial ischaemia reperfusion injury in rats. Eur. J. Pharmacol. 1999 364 159-168. 

CKs also play a role in leukocyte trafficking during ovarian function. For example, CKs are expressed and leukocytes accumulate within the ovulatory follicle and the corpus luteum. Hormonal and embryonic regulation of CKs are thought to be responsible. 

Arfors, K.-E., Lundberg, C., Lindbom, L., Lundberg, K., Beatty, R G., and Harland, J. M., A monoclonal antibody to the membrane glycoprotein complex CD 18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo, Blood, 69, 338, 1987. 

In an intestinal ischemia-reperfusion mouse model, acute inflammation is a rapid tissue response, presenting higher levels of TNF-a, adhesion molecules (E-selectin and ICAM-1), polymorphonuclear leukocytes accumulation, and NFkB activation. These processes are significantly attenuated in CORM-2-treated mice [71]. More recently, the same authors have found anti-inflammatory effect of CORM-2 in a mouse model of acute colitis, where this molecule has inhibited the production of keratinocyte chemoattractant and TNF-a in... 

Dong ZM, Murphy JW (1995) Intravascular cryptococcal culture filtrate (CneF) and its major component, glucuronoxylomannan, are potent inhibitors of leukocyte accumulation. Infect Immun 63(3) 770-778... 

Eriksson EE, Xie X, Weir J, Thoren P, Lindbom L. Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J Exp Med 2001 194 205-218. 

Walcheck, B., K. L. Moore, R. P. McEver, and T. K. Kishimoto. 1996. Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1 a mechanism that amplifies initial leukocyte accumulation on P-selectin in vitro. J. Clin. Invest. 98 1081-1087. 

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