Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Ascorbic acid leukocytes

The adrenal glands and pituitary glands have the highest tissue concentration of ascorbic acid. The brain, Hver, and spleen, however, represent the largest contribution to the body pool. Plasma and leukocyte ascorbic acid levels decrease with increasing age (152). Elderly people require higher ascorbic acid intakes than children to reach the same plasma and tissue concentration (153). [Pg.22]

Leukocyte ascorbic acid concentrations are generally considered to provide a better reflection of tissue stores than other blood components. Supporting evidence for this belief includes observations such as (i) leukocyte ascorbate levels drop slowly during ascorbic acid deficiency. [Pg.208]

Ramirez, J., and Flowers, N. C., 1980, Leukocyte ascorbic acid and its relationship to coronary heart disease in man. Am. J. Clin. Nutr. 33 2079-2087. [Pg.365]

Cunningham, J. J., Ellis, S. L., McVeigh, K. L., Levine, R. E., and Escandon-Calles, J., 1991, Reduced mononuclear leukocyte ascorbic acid contents in adults with IDDM consuming adequate dietary vitamin C, Metabolism 40 146-149. [Pg.399]

Further, significant positive correlations were observed between leukocyte ascorbic acid levels and IgG and IgM in humans (Vallance, 1977). Because of the disparity in results, no conclusions can be drawn concerning the action of ascorbic acid in antibody formation. [Pg.5]

Supplementary ascorbic acid given to adults results in transient increases in plasma levels and increased excretion in the urine, with a degree of augmentation relating to dose, but not uniformly, in these substrates. Both leukocyte ascorbic acid (LAA) and serum ascorbic acid (SAA) are significantly elevated over unsupplemented levels at 1 g/day, rising proportionately to maximum uptakes, at about 6 g/day. It has been... [Pg.128]

Absorption, Transport, and Excretion. The vitamin is absorbed through the mouth, the stomach, and predominantly through the distal portion of the small intestine, and hence, penetrates into the bloodstream. Ascorbic acid is widely distributed to the cells of the body and is mainly present in the white blood cells (leukocytes). The ascorbic acid concentration in these cells is about 150 times its concentration in the plasma (150,151). Dehydroascorbic acid is the main form in the red blood cells (erythrocytes). White blood cells are involved in the destmction of bacteria. [Pg.22]

In the recent review Carr et al. [54] considered potential antiatherogenic mechanisms of a-tocopherol and ascorbic acid. These authors concluded that these antioxidants are able to inhibit LDL oxidation, leukocyte adhesion to the endothelium, and vascular endothelial dysfunction. They also believe that ascorbic acid is more effective than a-tocopherol in the inhibition of these pathophysiological processes due to its capacity of reacting with a wide spectrum of oxygen and nitrogen free radicals and its ability to regenerate a-tocopherol. [Pg.857]

Biflavanoids in vegetables and fruits play a vital role in the storage of ascorbic acid in leukocytes, in the core of adrenal glands and in other organs. It also causes more effective expenses under ascorbic acid s deficiency in the organism. Phenolic compounds present in the organism, activate detoxication processes in the liver. The flavanoids exceed the tocopherols and carotenoids in terms of antioxidant effect. [Pg.415]

Some studies have suggested that ascorbic acid concentrations are lower in the leukocytes and platelets of oral contraceptive users (183) however, this has not been confirmed (184). [Pg.228]

The blood erythrocyte count is increased in smokers. The amount of carboxyhemoglobin may exceed 10% of the total hemoglobin in heavy smokers, and the increased number of cells compensates for impaired ability of the red cells to transport oxygen. The blood PO2 of the habitual smoker is usually about 5 mmHg (0.7 kPa) less than in the nonsmoker, whereas the PCO2 is unaffected. The blood leukocyte concentration is increased by as much as 30% in smokers, but the leukocyte concentration of ascorbic acid is greatly reduced. The lymphocyte count is increased as a proportion of the total leukocyte count. [Pg.457]

With adequate intake of vitamin C, plasma concentrations of total vitamin (ascorbic acid plus dehydroascorbic acid) are between 0.4 and 1.5mg/dL (23 to 85 jimol/L). The lower limit value may be seen in some cases with subclinical vitamin C deficiency and in older individuals. A value lower than 0.2mg/dL (llpmol/L) is considered deficient. The guidance reference interval for vitamin C levels in leukocytes is 20 to 53p,g/10 leukocytes (1.14 to 3.01 finol/leukocyte). A value in leukocytes of less than lOpg/10 leukocytes (0.57fmol/leukocyte) is considered deficient. ... [Pg.1107]

HIO. Heinemann, M., Influences of erythrocytes and of leukocytes on stability and transfer of ascorbic acid in human blood. J. Clin. Invest. 20, 467-471 (1941). [Pg.195]

Schmidt, K.H., Steinhilber, D., Moser, U. and Roth, H.J. (1988) L-Ascorbic acid modulates 5-lipoxygenase activity in human polymorphonuclear leukocytes. Int. Arch. Allergy Appl. Immunol. 85 441-445. [Pg.503]

With regard to the concentration of ascorbic acid in leukocytes, Briggs and Briggs (B13) reported a control value of 39 28 (SD) jug per 10 cells. On the assumption that the average diameter of the white cells is 12 jum (W9) and that the cell is spherical, the value of Briggs and Briggs (B13) can be calculated to be about 45 mg/100 ml. The mean normal values obtained by Butler and Cushman (B24), Lowry et al. (L8), and Bodansky et al. (B9) were about 30 mg/100 ml. The administration of oral contraceptives leads to significant decreases in the plasma, leukocytes, and platelet concentrations (Table 2). [Pg.253]

Effect of Oral Contraceptive Agents (OCA) and Vitamin C Supplementation on the Concentrations of Ascorbic Acid (mg/100 g) IN THE Leukocytes of Mature Women ... [Pg.254]

There is considerable evidence that smoking depletes ascorbic acid reserves (4,142,156,255-257,269), as shown by diminished whole blood, serum, and leukocyte ascorbate levels in smokers relative to nonsmoker controls. It would be presumptuous to say that this difference reflects an increased utilization acting in a protective capacity. Nevertheless, in the present state of our knowledge, it would seem a wise precaution for the compulsive heavy smoker to increase deliberately his ascorbate intake. [Pg.603]

Cooper, M. R., McCall, C. E., and DeChatelet, L. R. Stimulation of leukocyte hexose monophosphate shunt activity by ascorbic acid. [Pg.607]

Qoetzl. E. J., Wasserman.S. I.. Gigli, I., and Austen. K. F. Enhan< m t of random migration and chemotactic response of human leukocytes by ascorbic acid. J. Clin. Invest., 53 813-818.1974. [Pg.608]

Andrews and Wilson (1973) described a study wherein a 200 mg daily dose of vitamin C produced a high Incidence of thrombotic episodes associated with ascorbic acid compared with the placebo. There has also been described adverse vitro effects of a high concentration of ascorbic acid on human platelet structure and function (Cowen et al, 1975). Other hematological findings Include 1) leukocyte counts of subjects who consumed large doses of vitamin... [Pg.186]


See other pages where Ascorbic acid leukocytes is mentioned: [Pg.22]    [Pg.22]    [Pg.329]    [Pg.1107]    [Pg.676]    [Pg.77]    [Pg.343]    [Pg.23]    [Pg.22]    [Pg.22]    [Pg.329]    [Pg.1107]    [Pg.676]    [Pg.77]    [Pg.343]    [Pg.23]    [Pg.301]    [Pg.1066]    [Pg.1460]    [Pg.352]    [Pg.209]    [Pg.1106]    [Pg.109]    [Pg.882]    [Pg.153]    [Pg.132]    [Pg.599]    [Pg.9]    [Pg.11]    [Pg.142]    [Pg.145]    [Pg.150]   
See also in sourсe #XX -- [ Pg.208 , Pg.329 ]




SEARCH



Leukocyte acids

© 2024 chempedia.info