Leukemia disease

Leukemia—disease characterized by the proliferation of white blood cells Leukopenia—reduction in the number of white blood cells... 

Leukemia Disease characterized by the overproduction of immature or mature cells of various... 

Leukemia Disease reflected by abnormal white blood cells in bone marrow. 

Although the compounds were isolated in quantities of only a few milligrams per kilogram of cmde plant leaves, extensive work on a variety of animal tumor systems led to eventual clinical use of these bases, first alone and later in conjunction with other materials, in the treatment of Hodgkin s disease and acute lymphoblastic leukemia. Their main effect appears to be binding tightly to tubuHn, the basic component of microtubules found in eukaryotic cells, thus interfering with its polymerization and hence the formation of microtubules required for tumor proliferation (82). 

Vitamin D metaboUtes may therefore play an active role ia diseases related to these functions, ie, leukemia, cancer (breast, colon, prostate), and autoimmune diseases (AIDS, immune encephaUtis, and diabetes) (51, 141,193—197, 202, 203). 

Uses The nitrogen mustards are used clinically in the treatment of certain neoplasms (14). They have been used in treatment of Hodgkin s disease, lymphosarcoma, and leukemia (see Chemotherapeutics, anticancer). 

USP (Oncovin) vindesine sulfate [59917-39 ] C43H55N5O7 -H2S0 852.01 (50) chil-dren lymphocytic leukemia Hodgkin s disease non-Hodg-kin s lymphomas Wilm s tumor neuroblastoma rhabdomyosarcoma, investigational dmg (paresthesias, foot drop, double vision, etc) constipation ileus alopecia leu-kopenia (occasional) ... 

Irene Curie and Frederic Joliot received the Nobel Prize in physics. The award came too late for Irene s mother, who had died of leukemia in 1934. Twenty-two years later. Irene Curie-Joliot died of the same disease. Both women acquired leukemia through prolonged exposure to radiation. 

The Orphan Drug Act of 1983 was passed to encourage die development and marketing of products used to treat rare diseases. The act defines a rare disease as a condition affecting fewer than 200,000 individuals in die United States. The National Organization of Rare Disorders reports that there are more tiian 6000 rare disorders that affect approximately 25 million individuals. Examples of rare disorders include Tourette s syndrome, ovarian cancer, acquired immunodeficiency syndrome (AIDS), Huntington s disease, and certain forms of leukemia... 

Those at risk of developing tuberculosis (eg, those with Hodgkin s disease, severe diabetes mellitus, leukemia, and other serious illnesses and those receiving corticosteroids or drug therapy for a malignancy)... 

Warfarin is contraindicated in patients with known hypersensitivity to the drug, hemorrhagic disease, tuberculosis, leukemia, uncontrolled hypertension, gastrointestinal (GI) ulcers, recent surgery of the eye or... 

Hodgkin s disease, lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, testicular cancer, Kaposi s sarcoma, breast cancer Acute leukemia, combination therapy for various cancers... 

The "stealth" concept may offer two other opportunities for liposome application (1) Conventional immunoliposomes (see Sec. VI.C) have been shown to be removed rapidly firom the circulation by the MPS (Peeters et al., 1987). The combination of the stealth approach for longer circulation with the attachment of antibodies or antibody fragments may provide a means of delivery of drugs to their sites of action with a high degree of specificity. This could be useful for treating leukemia, graft-vs.-host diseases, and HIV disease. 

Term to UltraLink myeloblastic leukemia Concept Type DISEASE Normalized term myeloid leukemia Synonyms ... 

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