Lenticular opacities

The answer is a. (Hardman, pp 885-8870 Lovastatin should not be used in patients with severe liver disease. With routine use of lovastatin, serum transaminase values may rise, and in such patients the drug may be continued only with great caution. Lovastatin has also been associated with lenticular opacities, and slit-lamp studies should be done before and one year after the start of therapy There is no effect on the otic nerve. The drug is not toxic to the renal system, and reports of bone marrow depression are very rare There is a small incidence of myopathy, and levels of creatinine kinase should be measured when unexplained muscle pain occurs. Combination with cyclosporine or clofibrate has led to myopathy There is no danger in use with bile acid sequestrants. 

Ophthalmic effects There was a high prevalence of baseline lenticular opacities in the patient population included in the early clinical trials with lovastatin. 

Gualtieri, C.T., Lefler, W.H., Guimond, M., and Staye, J.I. (1982) Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine. Am / Psychiatry 139 1178-1180. 

Extrapyramidal reactions include parkinsonism, acute muscular dystonias, akathisia, tardive dyskinesia and malignant neuroleptic syndrome. They can also cause hypersensitivity reaction including cholestatic jaundice, skin rash, urticaria, photosensitivity and contact dermatitis. There is also blue pigmentation of skin, lenticular opacities on prolonged use of drug. 

In 696 patients taking atorvastatin and 235 taking lovastatin for 1 year there were no significant differences in the distribution of lenticular opacities or cortical opacities and spokes between the two drugs (10). 

A number of industrial chemicals were screened using AFNOR protocols with rabbits as the test systems. Information on the appearance and irritancy potential of different chemicals (and the classification thereof) offers valuable clues to the worker to avoid skin injury (Table 16-4). Certain drugs normally used by humans can cause adverse effects on eyes. The types of ocular disturbance are blurring of vision and diplopia, impairment of visual acuity, yellow vision (xanthopsia), corneal opacities, and lenticular opacities and drugs producing or precipitating the formation of cataract, which have been implicated with the use of candidate drugs. 

Ingestion of an unspecified dose of DNOC for 3 years was associated with a pearly swollen cataract of the left eye in a woman (Quick 1937). The right eye, which had punctate central lenticular opacity, eventually became blind 1 month after the cataract was diagnosed. A slight yellow pigmentation of the conjunctiva also appeared periodically during the 3-year treatment. 

Grading and/or Progression of Chlorpromazine-Related Lenticular Opacities... 

Aleo MD, Doshna CM, Navetta KA (2005) Ciglitazone-induced lenticular opacities in rats in vivo and whole lens explant culture evaluation. The Journal of Pharmacology and Experimental Therapeutics 312 1027-1033. 

Observational studies In a retrospective study of dose escalation of deferasirox to above 30 mg/kg/day in 264 heavily iron-loaded patients, gastrointestinal hemorrhage and lenticular opacities developed as suspected adverse reactions in one patient each, but no details were given [16 ]. There was no worsening of renal or hepatic function. 

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