Leishmania amazonensis

Al-Abdely HM, et al. Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous leishmaniasis and visceral leishmaniasis. Antimicrob Agents Chemother 1998 42 2542. 

Verwaerde C, Thiam K, Delanoye A, et al. Systemic delivery of an adenovirus expressing EBV-derived vIL-10 in mice infected with Schistosoma mansoni or Leishmania amazonensis controversial effects on the development of pathological parameters. Eur Cytokine Netw 1999 10(2) 161-170. 

Compagno, D., Lampe, J.N., Bourget, C., Kutyavin, I.V., Yurchenko, L., Lukhtanov, E.A. and Gom, V.V. (1999) Antisense oligonucleotides containing modified bases inhibit translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin. J. Biol. Chem., 274, 8191-8198. 

Araujo, C.A.C., Alegrio, L.V., Castro, D., Lima, M.E.F. and Leon, L.L. (1998) Leishmania amazonensis in vivo experiments with diarylheptanoids from Leguminosae and Zingiberaceae plants. Memdrias do Instituto Oswaldo Cruz 93, 306-310. 

Several l,3,4-thiadiazolium-2-aminides were also tested against pro-mastigote and amastigote forms of Leishmania amazonensis. Parasites were assayed with or without the drugs in axenic media, using pentamidine isethionate as a reference drug. The most active compounds were the... 

Figure 4- FAB-MS of native glycosphingolipid from Leishmania amazonensis...

Cryptotanshinone is a quinoid diterpene with a nor-abietane skeleton isolated from roots of the Iranian medicinal plant Perouskia abronatoides L. which exhibited leishmanicidal activity in vitro. These findings provide a rationale for the traditional use of the roots in Iran as a constituent of poultices for treatment of cutaneous leishmaniasis [199], More recently, Valderrama et al. [200] synthesized several eurylfurylquinones and hydroquinones from activated monosubstituted 1,4-benzoquinones and studied their in vitro activities against Leishmania amazonensis. 

Antonine, J. C., Prina, E., Jouanne, C. and Bongrand, P. (1990) Parasitophorous vacuoles of Leishmania amazonensis- mkcted macrophages maintain an acidic pH. Infect. Immun. 58 779-787. 

The in vitro antileishmanial activity of lignans from Doliocarpus dentatus (Dilleniaceae) against amastigotes of Leishmania amazonensis was reported by Sauvain et al. [178], The lignans isolated were (+)-pinore-sinol, (+)-medioresinol and (-)-lirioresinol B. 

Lin YC, Hsu JY, Chiang SC et al. Distinct overexpression of cytosolic and mitochondrial tryparedoxin peroxidases results in preferential detoxification of different oxidants in arsenite-resistant Leishmania amazonensis with and without DNA amplification. Mol Biochem Parasitol 2005 142 66-75. 

Chen DQ, KoUi BK, Yadava N et al. Episom expression of lecific sense and antisense mRNAs in Leishmania amazonensis Modulation of gp63 level in promast tes and thdr infection of macrophages in vitro. Infect Immun 2000 68(l) 80-6. 

Foumet A, Ferreira ME, Arias AR, Ortiz ST, Fuoites S, Nakayama H, Schinini A, Hocquemiller R (1996) In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new wmld cutaneous leishmaniasis caused by Leishmania amazonensis. Antimicrob Agtaits Chemother 40 2447-2451... 

Antileishmaniasis - in vivo against Leishmania amazonensis (SC and intrapaw, mouse) at 100.0 and 200.0 mg/kg Leishmania venezuelensis (intrapaw, mouse) at 100.0 mg/kg. Antileishmaniasis - in vitro against Leishmania donovani, IC50 2.22 pM. 

De Souza, G.F.P., Yokoyama-Yasunaka, J.K.U., Seabra, A.B., Miguel, D.C., De Oliveira, M.G., Uliana, S.R.B. Leishmanicidal activity of primary S-nitrosothiols against Leishmania major and Leishmania amazonensis implications for the treatment of cutaneous leishmaniasis. Nitric Oxide 15(3), 209-216 (2006)... 

Elatol has been further isolated from two species of Brazilian origin Laurencia dendroidea, and L. microcladia. This sesquiterpene displays interesting activity against the protozoa Leishmania amazonensis, and it is palatable for the sea urchin Echinometra lucunter (Lhuillier et al, 2009 Oliveira dos Santos et al, 2010). 9-Deoxyelatol has recently been isolated from Laurencia mariannensis collected in China (Ji et al, 2007a). 

Oliveira dos Santos, A., Veiga-Santos, P., Ueda-Nakamura, T Prado Dias Filho, B., Bueno Sudatti, D., Bianco, E.M., Pereira, R.C., and Vataru Nakamura, C. (2010) Effect of elatol, isolated from red seaweed Laurenda dendroidea, on Leishmania amazonensis. Mar, Drugs, 8, 2733-2743. 

Lohman, K.L., Langer, RJ. and McMahon-Pratt, D. 1990. Molecular cloning and characterization of the immunologically protective surface glycoprotein of GP46/M-2 of Leishmania amazonensis. Proc. Natl. Acad. Sci. U.S.A. 87 8393-8397. 

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