Left ventricular hypertrophy and

Cardiovascular diseases hypertension, coronary heart disease, cardiomyopathy, left ventricular hypertrophy, and arrhythmia. 

Ichihara, S., Senbonmatsu, T., Price, E., Jr., et al. 2001. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation 104 346-351. 

Hofmeister (5) prepared 4-phenyltetrahydroisoquinolinium derivatives, (HI), for the treatment of left-ventricular hypertrophy and related thrombotic disorders. 

A 57-year-old man with bipolar disorder taking olanzapine, lithium, and other drugs had underlying mitral valve prolapse, left ventricular hypertrophy, and His bundle anomalies he died suddenly, probably because of a cardiac dysrhythmia. 

Sublingual nifedipine, given for hypertensive crises in elderly patients, can cause adverse effects associated with a precipitous fall in blood pressure, even at low doses. In 93 consecutive hypertensive patients without coronary heart disease, aged 65 years or over, nifedipine reduced blood pressure significantly, increased heart rate, and relieved sjmptoms associated with raised blood pressure (9). However, there were electrocardiographic changes consistent with myocardial ischemia in six of 55 patients with left ventricular hypertrophy and in one patient without left ventricular hypertrophy. 

Repetitive abuse can cause crusting skin lesions and telangiectasis (angioma or hyperemic spots). Tracheobronchial irritation with dyspnea and hemoptysis has been reported. Withdrawal from industrial exposure has resulted in respiratory failure, left ventricular hypertrophy, and myocardial infarctions. Damage to the lungs, liver, kidneys, bone marrow, and brain is possible. Nitrite inhalants are thought to be carcinogenic and immunosuppressive. Tolerance occurs. 

Vasan RS, Benjamin EJ, Larson MG, Leip EP, Wang TJ, Wilson PW, et al. Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction the Framingham heart study. JAMA 2002 288 1252-9. 

Sasaki M, Oki T, luchi A, et al. Relationship between the angiotensinconverting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension M-mode and pulsed Doppler echocardiographic smdies. J Hypertens 1996 14 1403-1408. 

Spirito P, BelloneP, Harris KM, et al. Magnitudeof left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl JMed 2000 342 1778-1785. 

The most important modifiable risk factor for stroke is hypertension. The treatment of hypertension, beginning in the midtwentieth century, is thought to be primarily responsible for the drastic reduction in stroke death rates between 1950 and 1980 in the United States. A second very important risk factor for stroke is cardiac disease. Patients with coronary artery disease, congestive heart failure, left ventricular hypertrophy, and especially atrial fibrillation are at increased risk of stroke. In fact, the presence of atrial fibrillation is one of the most potent risk factors for ischemic stroke, with stroke... 

Minoxidil has particularly adverse consequences in hypertensive patients who have left ventricular hypertrophy and diastolic dysfunction. Such poorly compliant ventricles respond subopti-mally to increased volume loads, with a resulting increase in left ventricular filling pressure. This likely contributes to the increased pulmonary artery pressure seen with minoxidil therapy in hypertensive patients and is compounded by the drug-induced retention of salt and water. Cardiac failure can result from minoxidil therapy in such patients the potential for this complication can be reduced but not prevented by effective diuretic therapy. Pericardial effusion is an uncommon but serious complication of minoxidil. Although more commonly described in patients with cardiac failure and renal failure, pericardial effusion can occur in patients with normal cardiovascular and renal function. Mild and asymptomatic pericardial effusion is not an indication for discontinuing minoxidil, but the situation should be monitored closely to avoid progression to tamponade. Effusions usually clear when the drug is discontinued but can recur if treatment with minoxidil is resumed. 

Scfawitter J, DeMarco T, Globits S, Sakuma H, Klinski C, Chatteijee K, Parmley WW, Higgins CB. Influence of felodipine on left ventricular hypertrophy and systolic function in or-tiicptic heart transplant recipients possible interaction with cyclospcxine medicatioa J Heart LungTransplant 999) 18,1003-13. 

Han, S., Z. Zheng, and D. Ren. 2002. [Effect of Salvia miltiorrhiza on left ventricular hypertrophy and cardiac aldosterone in spontaneously hypertensive rats.] /. Huazhong Univ. Sci. Technol. Med. Sci. 22(4) 302-304. 

Artham, S.M., Lavie, C.J., Milani, R.V., Patel, D.A., Verma, A., Ventura H.O. (2009). Clinical impact of left ventricular hypertrophy and implication for regression. Prog. Cardiovasc. Dis. 52 153-167. 

Zde, M.R., Desantis, S.M., Baicu, C.F., Stroud, R.E., Thompson, S.B., McClure, C D., Mehurg, S.M., Spinale, RG. (2011). Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure. Circ. Heart. Fail. 4(3) 246-256. 

Shenasa M, Shenasa H, El-Shetif N (2015) Left ventricular hypertrophy and arrhythmogenesis. Card Electrophysiol Clin 7 207-220... 

DE Groot (1964) heart symptoms appear during the third decade. Left ventricular hypertrophy and/or electrocardiographic changes (see fig. 2) compatible with diffuse myocardial lesions are found in over 30 per cent of affected subjects. Heart failure seems rare (Hornbostel 1952, both cases). 

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