Enzymes/genes

ROSEWicz s, LEWIS L D, WANG X Y, LiDDLE R A, LOGSDON c D (1989) Pancreatic digestive enzyme gene expression effects of CCK and soybean trypsin inhibitor. dm J Physiol. 256 G733-8. 

Taken together, these results show that specific induction of several permease- as well as enzyme-genes in Saccharomyces cerevisiae is a complex mechanism involving distinct combinations of specific and pleiotropic, positive and negative regulatory proteins (Fig. 4). 

R. eutropha, formerly known as Alcaligenes eutrophus, has been used for the commercial production of P(3HB-co-3HV) [72]. This bacterium grows well in a relatively inexpensive minimal medium and accumulates a large amount of P(3HB) under the unbalanced growth condition. In R. eutropha, acetyl-CoA is converted to P(3HB) by three enzymes (genes) /J-ketothiolase (phaA), aceto-acetyl-CoA reductase (phaB), and PHA synthase (phaC) [6]. 

Further studies led to the development of a recombinant microorganism containing a desulfurization enzyme gene at the tail end of a promoter composed of (a) a DNA characterized by a claimed sequence (No. 1 in the referred application) and having... 

Schunkert H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J Mol Med 1997 75 867-875. 

WlNKELMANN BR, NAUCK M, KlEIN B, Russ AP, Bohm BO, Siekmeier R, Ihn-ken K, Verho M, Gross W, Marz W. Deletion polymorphism of the angiotensin I-converting enzyme gene Is associated with increased plasma angiotensin-con-verting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease. Ann Intern Med 1996 125 19-25. 

Harrap SB, Davidson R, Connor JM, Soubrier F, Corvol P, Fraser R, Foy CJW, Watt GCM. The angiotensin I-con-verting enzyme gene and presdisposition to high blood pressure. Hypertension 1993 21 455-460. 

Buikema H, Pinto YM, Rooks G, Grandjean JG, Schunkert H, van Gilst WH. The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences... 

Prasad A, Narayanan S, Waclawiw MA, Epstein N, Quyyumi AA. The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity. J Am Coll Cardiol 2000 36 1579-1586. 

Butler R, Morris AD, Burchell B, Struthers AD. DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans. Hypertension 1999 33 1164-1168. 

Perticone F, Ceravolo R, Maio R, Ventura G, Zingone A, Perrotti N, Mat-tioli PL. Angiotensin-converting enzyme gene polymorphism is associated with endothelium-dependent vasodilation in never treated hypertensive patients. Hypertension 1998 31 900-905. 

Montgomery H, Clarkson P, Barnard M, Bell J, Brynes A, Dollery C, Haj-nal J, Hemingway H, Mercer D, Jarman P, Marshall R, Prasad K, Rayson M, Saeed N, Talmud P, Thomas L, Jubb M, World M, Humphries S. Angioten-sin-converting-enzyme gene insertion/deletion polymorphism and response to physical training. Lancet 1999 353 541— 45. 

Tian B, Meng QC, Chen Y-F, Krege JH, Smithies O, Oparil S. Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function. Hypertension 1997 30[part I] 128—133. 

Yamauchi M, Maezawa Y, Mizuhara Y et al. Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients. Hepatology 1995 22 1136-1142. 

Diabetes insipidus occurs with a loss of vasopressin production in the Brattleboro rat model 330 Mutations and knockouts of peptide-processing enzyme genes cause a myriad of physiological problems 330 Neuropeptides play key roles in appetite regulation and obesity 330 Enkephalin knockout mice reach adulthood and are healthy 331 Neuropeptides are crucial to pain perception 331... 

Mutations and knockouts of peptide-processing enzyme genes cause a myriad of physiological problems. 

Willey JC, Coy E, Brolly C, Utell MJ, Frampton MW, Hammersley J, Thilly WG, Olson D, Cairns K (1996) Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells. Am J Respir Cell Mol Biol 14(3) 262-271. 

Yu L, Romero DG, Gomez-Sanchez CE, Gomez-Sanchez EP. 2002. Steroidogenic enzyme gene expression in the human brain. Mol Cell Endocrinol 190 9-17. 

Rigat, B., Hubert, C., Alhencgelas, F., Cambien, F., Corvol, P., and Soubrier, F. (1990) An insertion deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86, 1343-1346. 

Yang, J.D., Feng, G., Zhang, J., et al. (2000) Association between angiotensin-converting enzyme gene and late onset Alzheimer s disease in Han Chinese. Neurosci. Lett., 295, 41 4. 

Cheng, C.Y., Hong, C.J., Liu, H.C., Liu, T.Y., Tsai, S.J. (2002) Study of the association between Alzheimer s disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes. Eur. Neurol., 47, 26-29. 

Scacchi, R., De Bernardini, L., Mantuano, E., et al. (1998) DNA polymorphisms of apoUpo-protein B and angiotensin I-converting enzyme genes and relationships with Upid levels in Italian patients with vascular dementia or Alzheimer s disease. Dement. Geriatr. Cogn. Disord., 9, 186-190. 

Wu, C., Zhou, D., Guan, Z., Fan, J., Qio, Y. (2002) The association between angiotensin I converting enzyme gene polymorphism and Chinese late onset Alzheimer disease. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 19, 401-404. 

Purandare, N., Oude Voshaar, R.C., Davidson, Y., et al. (2006) Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia a pilot study. J. Am. Geriatr. Soc., 54, 1395-1400. 

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