LD50 dose

Typical units for LDjq values are milligrams or grams of material per kilogram of body weight (mg/kg or g/kg, recall that 1 kg = 2.2 pounds). Never be exposed to an LD50 dose of a hazardous chemical- by definition, there is a 50% chance this will kill you and if you survive you are not going to be in good shape. Pay close attention to the permissible exposure level (PEL) instead. This is a more realistic determination of the maximum safe exposure to a material and is usually based on the known effects of the chemical on humans, rather than laboratory animals. 

H LD50 Doses represent the lowest dose tested per... 

The most likely toxicity value to be found in the literature is the LD50 (dose lethal to 50% of the animals) for some laboratory species, usually rat or mouse. This value may be obtained by plotting on probit paper the fraction of experimental animals killed against the acute dosage. There Is seldom enough information to permit extrapolation to a dosage at which only a very small (e.g., 1%) fraction of the animals would be killed, much less to an acceptable risk level. Handy and Schindler (12), however, assum ... 

Birds seem comparatively resistant to diflubenzuron acute oral LD50 doses exceed 2000 mg/kg body weight (BW) dietary concentrations <4640 mg/kg FW are tolerated for at least 8 days and forest birds seem unharmed by recommended diflubenzuron application procedures to control pestiferous insects, except for a possible loss in fat reserves. Intraspecies differences in ability to metabolize diflubenzuron are probably large different strains of domestic chickens show significant differences in ability to accumulate and retain this compound. 

Single oral LD50 dose of 2000 mg/kg body weight (BW) signs of poisoning evident within 10 min and mortalities within 1-2 days postadministration. Remission took up to 1 month... 

Nitro-4-hydroxyphenyl- Single oral LD50 dose of 17.4 mg/kg BW 2... 

Silvisar-510 (mixture of Single oral LD50 dose >320 mg/kg BW appetite loss... 

Radiation adversely affects limb regeneration of amphibians, alters DNA metabolism, and increases the frequency of chromosomal aberrations and liver lesions (Table 32.25). In some species of amphibians and reptiles, as in many mammals, mortality rates after acute exposure to radiation do not stabilize within 30 days — effectively invalidating the conventional LD50 (30-day postexposure) value. In the rough-skinned newt (Taricha granulosa), for example, the minimal LD50 dose at 200 days after irradiation was 2.5 Gy, compared with 350 Gy at 30 days (Willis and... 

A pronounced drop in the body temperature of mice was observed following the injection of a methanol extract of G. toxicus. This extract was used throughout the study and had an estimated LD50 dose of 20 mg/kg for mice (Figure l). 

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