LD50 Lethal Dose

Several of the commonly used rubber chemicals tike accelerators, retarders, antidegradants, etc. are classified as hazardous on account of values of LD50 (lethal dose 50%) [6]. Many of the guanidine... 

GO) = gavage in oil (GW) = gavage in water Gd = gestation day Hemato = hematological LD50 = lethal dose, 50% kill LOAEL = lowest-observable-adverse-effect level M = male Metab = metabolic Musc/skel = musculoskeletal NOAEL = no-observable- adverse-effect level ... 

The inherent toxicity of a material is measured by tests on animals. It is usually expressed as the lethal dose at which 50 per cent of the test animals are killed, the LD50 (lethal dose fifty) value. The dose is expressed as the quantity in milligrams of the toxic substance per kilogram of body weight of the test animal. 

LOAEL = lowest-observed-adverse-effect level NOAEL = no-observed-adverse-effect level mg/kg/day = mi 11igram/ki1ogram/day ND = no data LD50 = lethal dose, mortality 50%. 

Witkin (1956) reported intravenous (iv), intraperitoneal (i.p.), and oral LD50 (lethal dose for 50% of the animals) values for mice and rats, and i.v. LD50 values for dogs. Similar to hydrazine, the route of administration had minimal... 

Nickel salts administered by intravenous or subcutaneous injection are comparatively toxic. For all routes of parenteral administration, the LD50 (lethal dose to 50% of the sample) range for injected nickel salts is 6 mg Ni/kg BW for dogs given nickel oxide intravenously to 600 mg Ni/kg BW for mice given nickel disodium F.DTA intraperitoneally (Nielsen 1977). 

LD50 Lethal Dose 50% (dose killing 50% of tested population)... 

In an LD50 (lethal dose, 50% kill) test with Sprague-Dawley rats (sex not specified), an LD50 of 15,840 mg/kg was reported for 14-day-old rats (Kimura et al. 1971). Values of 32,340 and 28,710 mg/kg were reported for young (80-160 g) and older (300-470 g) adults, respectively. An LD50 for newborns could not be derived because of dose-volume limitations. 

LD50 Lethal dose 50 The dose calculated to kill 50% of a subject... 

LD50 = lethal dose, 50% mortality LOAEL = lowest... 

Quantal dose-response curves based on all-or-none responses. A. Relationship between the dose of phenobarbital and the protection of groups of rats against convulsions. B. Relationship between the dose of phenobarbital and the drug s lethal effects in groups of rats. ED50, effective dose, 50% LD50, lethal dose, 50%. 

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