Laxatives, contact

Bisacodyl (9) is a contact laxative that may be given orally or rectaHy. It is often used for evacuation of the bowel prior to surgery or diagnostic examination. It may obviate the need for a cleansing enema. 

The effects that the drug has on the gastrointestinal tract are quite severe. Fentanyl use, whether clinical or recreational, will cause constipation in the user. It is recommended that patients always take laxatives or stool softeners when using fentanyl. At least one bowel movement every two to three days is recommended. Longer periods of time between movements can result in damage to the colon, intestines, and stomach. If it has been longer than three days since the last bowel movement, patients are instmcted to contact their physician,... 

On contact with gastric acid, magnesium carbonate reacts in the stomach to form soluble magnesium chloride and carbon dioxide. Magnesium carbonate should therefore not be used as an antacid by those individuals whose stomachs cannot tolerate the evolution of carbon dioxide. Some magnesium is absorbed but is usually excreted in the urine. As with other magnesium salts, magnesium carbonate has a laxative effect and may cause diarrhea. 

Siegel, R. 1979. Ginseng abuse syndrome Problems with the panacea. JAMA 241, 1614-1615. Siegers, C. 1992. Anthranoid laxatives and colorectal cancer. Trends Pharmacol. Sci. 13, 229-231. Simpson, E., Law, S., and Storrs, F. 2004. Prevalence of botanical extract allergy in patients with contact dermatitis. Dermatitis 15, 67-72. 

Propylene glycol is used as solvents in many formulations (e.g., oral, topical, and parenteral routes) for poorly soluble compounds such as phenobarbital, phenytoin, diazepam, and multivitamin concentrates. Because of the limited metabolic pathways in children younger than four years, number of adverse events has been described (laxative effects per os, contact dermatitis) but mainly serious systemic CNS depression. Seven of... 

A06A B Contact laxatives Two different types of laxatives, which have a primary effect on intestinal motility, are the anthranoid glycosides and castor oil. 

Geboes K, Nijs G, Mengs U, Geboes KPS, Van Damme A, de Witte P. Effects of "contact laxatives" on intestinal and colonic epithelia cell proliferation. Pharmacology 1993 47(Suppl 1) 187—95. 

Dithranol (anthralin, cignolin) is a mandatory irritant in psoriasis therapy. Staining of clothes, skin, nails, and hair are frequent and should be explained to patients. An unusual cutaneous anthralin-like staining of the perineum may follow use of danthrone, as a laxative. Danthrone (1,8-dihydroxyanthroquinone) is closely related to dithranol (1,8,9-anthracenetriol). Contact allergy has not been reported. 

Regulatory FDA 21 CFR 172.878,178.3620,573.680 DOT nonregulated OSHA nonhazardous SARA 311/312/313 nonreportable Australia, Canada DSL, China, EC, Japan, Korea listed Properties Water-wh. transparent liq., odorless sol. in hydrocarbons negligible sol. in water sp.gr. 0.827-0.836 dens. 6.94-7.02 Ib/gal vise. 9.2-10.6 cSt (40 C) pour pt. 15 F flash pt. 320 F ref. index L4613. Toxicology STEL 10 mg/m (as oil mist) relatively nontoxic by ingestion unless aspiration occurs (which may cause pneumonitis and may be fatal) laxative props, may result in abdominal cramps, diarrhea minimally irritating to eyes on direct contact... 

Toxicology STEL 10 mg/m (as oil mist) relatively nontoxic by ingestion unless aspiration occurs (which may cause pneumonitis and may be fatal) laxative props, may result in abdominal cramps, diarrhea minimally irritating to eyes on direct contact TSCA listed Precaution May react with strong oxidizing agents spillages may be slippery... 

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