Laxative activity

The charcoal passage test can be used for evaluation of laxative activity as well as for inhibition of intestinal motility. 

Dietary fibre consists of all components of plant cell walls not digested by human alimentary enzymes. Chemically, fibre is a mixture of cellulose, lignin, heteropoly-saccharides (hemicelluloses), acidic polysaccharides and pectin. In the colon, bacteria hydrolyse up to 15% of cellulose and 70-95% of other polysaccharides giving rise to volatile gases and low molecular weight fatty acids (acetic, butyric etc.) which have weak laxative activity. In addition the cellulosic and non-cellulosic polysaccharides are hydrophilic and absorb large amounts of fluid from the gut lumen, increasing in bulk as they do so. This is exactly the... 

Several studies have been conducted in order to establish and better understand the mode of action of anthranoid laxatives. For example, Lemli [14] presented a review of the study of the mode of action of sennosides, Fig. (1) the active constituents of the senna drug. An interaction between rhein-anthrone, the active metabolite of sennosides, and the immune cells of the colon is suggested as a base for laxative activity. Several studies aimed to... 

Aperient Substance that exerts a mild laxative activity. 

No studies on the use of unprocessed fo-ti during pregnancy or lactation were identified. No contraindications for use during pregnancy or lactation are listed in two traditional Chinese medicine texts (Bensky et al. 2004 Chen and Chen 2004). Based on stimulant laxative activity and an incomplete understanding of reports of hepatotoxic-ity associated with the incompletely processed tuber, use during pregnancy or lactation is not recommended except under the supervision of a qualified healthcare practitioner. 

Alder buckthorn (Rhamnus frangula). A member of the Rhamnaceae endemic to Europe, north west Asia, and north Africa whose bark is used to prepare extracts with laxative activity and for mordant dyeing of wool (sandy brown to red-brown) on account of its contents of emodin, frangulins, chrysophanol, physcion, and other anthranoids. 

C15H20O3, Mr 248.32, golden yellow platelets, mp. 104-106°C, [a] -17° (ether). A sesquiterpene of the bisabolene type with laxative activity from Perezia (Asteraceae) and Jungia species. 

Activity P. is a strong irritant of the skin and mucous membranes, has laxative activity, and is a mitotic toxin since it inhibits topoisomerase II. Like 9-deoxypodophyllotoxin, it is cytotoxic and possibly cancerogenic. P. shows anti-HIV-activity. 

Loewe, S. Laxative activity of triphenylmethane derivatives. 1. Relationship between structure and activity of phenolphthalein congeners. J. Pharmacol. Exp. Ther. 1948, 94, 288-298. 

The fruits are used as antipyretic, expectorant, and to treat Angina pectoris. The seeds possess a laxative activity for treatment of constipations. 

Karaya gum is not digested or absorbed by humans. It has laxative activities, due to the ability of its granules to absorb water and swell up to 100 times their original volume, forming a discontinuous type of mucilage. 

Dietary Supplements/Health Foods. Ground seeds or husks used in various dietary supplement formulations for increased fiber, cholesterol reduction, laxative activity, for example, weight loss products. 

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