Laser-induced interstitial thermotherapy

Mack, M.G., Straub, R., EicMer, K., Sdllner, O., Lehnert, T., VogI, T.J. Breast cancer metastases in liver Laser-induced interstitial thermotherapy. Local tumor control rate and surival data. Radiology 2004 233 400-409... 

Mack MG, Straub R, Eichler K et al (2004) Breast cancer metastases in liver laser-induced interstitial thermotherapy - local tumour control rate and survival data. Radiology 233 400-409... 

Unresectable and chemorefractory malignant tumors in the liver are a major cause of death in solid tumors. Potentially curative surgery is uncommon for these patients. A number of liver-directed therapies are now available and are making important contributions to quality of life, prolonged time to liver progression, and overall survival. Limited surgery involving laparoscopy and percutaneous access approaches enables local tumor resection, cryotherapy, laser-induced interstitial thermotherapy, and radiofrequency ablation. 

Laser-induced interstitial thermotherapy represents a minimally invasive therapy, where the cancerous tissue is irradiated by laser light guided through an optical fiber. Planning the operation anticipates the knowledge of the absorption and scattering properties of cancerous tissue compared to healthy tissue. Several optical and computational techniques have been developed that can... 

Kahn T, Bettag M, Ulrich F, Schwarzmaier HJ, Schober R, Furst G, Modder U (1994) MRI-guided laser-induced interstitial thermotherapy of cerebral neoplasms. J Corn-put Assist Tomogr 18 519... 

Recently there has been great interest in the further developments of interstitial procedures such as laser-induced interstitial thermotherapy (LITT), RF ablation, and microwave ablation and cryotherapy. 

Palliative treatment options for recurrent head and neck cancer are limited by the proximity of vital vascular and neural structures and the aggressive nature of most of these tumors. Laser-induced interstitial thermotherapy (LITT) is a recently developed minimally invasive treatment modality. It is a minimally invasive technique for local tumor destruction within solid organs. 

Fig. 7.1.1. a The drawing shows the set-up for laser-induced interstitial thermotherapy (LITT). b Internally cooled power laser application system with laser applicator... 

Kahn, T., Harth, T, Kiwit, J. C., Schwarzmaier, H. J., Wald, C., and Modder, U. (1998). bivivo MRI thermometry using a phase-sensitive sequence Preliminary experience during MRI-guided laser-induced interstitial thermotherapy of brain mmors, /. Magn. Reson. Imaging 8, 160-164. 

Bremer C, Kreft G, Filler T, et al (2002) Accuracy of non-enhanced MRI to monitor histological lesion size during laser-induced interstitial thermotherapy. Eur Radiol 12 237-244... 

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